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Cancer epigenetics: from mechanism to therapy.
Dawson MA, Kouzarides T. Dawson MA, et al. Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013. Cell. 2012. PMID: 22770212 Review.
Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.
Waibel M, Solomon VS, Knight DA, Ralli RA, Kim SK, Banks KM, Vidacs E, Virely C, Sia KC, Bracken LS, Collins-Underwood R, Drenberg C, Ramsey LB, Meyer SC, Takiguchi M, Dickins RA, Levine R, Ghysdael J, Dawson MA, Lock RB, Mullighan CG, Johnstone RW. Waibel M, et al. Among authors: dawson ma. Cell Rep. 2013 Nov 27;5(4):1047-59. doi: 10.1016/j.celrep.2013.10.038. Epub 2013 Nov 21. Cell Rep. 2013. PMID: 24268771 Free PMC article.
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T. Dawson MA, et al. Nature. 2011 Oct 2;478(7370):529-33. doi: 10.1038/nature10509. Nature. 2011. PMID: 21964340 Free PMC article.
Demethylases go mental.
Dawson MA, Bannister AJ. Dawson MA, et al. Mol Cell. 2010 Apr 23;38(2):155-7. doi: 10.1016/j.molcel.2010.04.002. Mol Cell. 2010. PMID: 20417593 No abstract available.
LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease.
Griffiths DS, Li J, Dawson MA, Trotter MW, Cheng YH, Smith AM, Mansfield W, Liu P, Kouzarides T, Nichols J, Bannister AJ, Green AR, Göttgens B. Griffiths DS, et al. Among authors: dawson ma. Nat Cell Biol. 2011 Jan;13(1):13-21. doi: 10.1038/ncb2135. Epub 2010 Dec 12. Nat Cell Biol. 2011. PMID: 21151131 Free PMC article.
Three distinct patterns of histone H3Y41 phosphorylation mark active genes.
Dawson MA, Foster SD, Bannister AJ, Robson SC, Hannah R, Wang X, Xhemalce B, Wood AD, Green AR, Göttgens B, Kouzarides T. Dawson MA, et al. Cell Rep. 2012 Sep 27;2(3):470-7. doi: 10.1016/j.celrep.2012.08.016. Epub 2012 Sep 20. Cell Rep. 2012. PMID: 22999934 Free PMC article.
Targeting epigenetic readers in cancer.
Dawson MA, Kouzarides T, Huntly BJ. Dawson MA, et al. N Engl J Med. 2012 Aug 16;367(7):647-57. doi: 10.1056/NEJMra1112635. N Engl J Med. 2012. PMID: 22894577 Review. No abstract available.
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.
Dawson MA, Bannister AJ, Göttgens B, Foster SD, Bartke T, Green AR, Kouzarides T. Dawson MA, et al. Nature. 2009 Oct 8;461(7265):819-22. doi: 10.1038/nature08448. Epub 2009 Sep 27. Nature. 2009. PMID: 19783980 Free PMC article.
Phosphorylation of histone H3 Thr-45 is linked to apoptosis.
Hurd PJ, Bannister AJ, Halls K, Dawson MA, Vermeulen M, Olsen JV, Ismail H, Somers J, Mann M, Owen-Hughes T, Gout I, Kouzarides T. Hurd PJ, et al. Among authors: dawson ma. J Biol Chem. 2009 Jun 12;284(24):16575-83. doi: 10.1074/jbc.M109.005421. Epub 2009 Apr 10. J Biol Chem. 2009. PMID: 19363025 Free PMC article.
Bromodomains as therapeutic targets in cancer.
Barbieri I, Cannizzaro E, Dawson MA. Barbieri I, et al. Among authors: dawson ma. Brief Funct Genomics. 2013 May;12(3):219-30. doi: 10.1093/bfgp/elt007. Epub 2013 Mar 28. Brief Funct Genomics. 2013. PMID: 23543289 Review.
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