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Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner.
Van de Vyver T, Bogaert B, De Backer L, Joris F, Guagliardo R, Van Hoeck J, Merckx P, Van Calenbergh S, Ramishetti S, Peer D, Remaut K, De Smedt SC, Raemdonck K. Van de Vyver T, et al. Among authors: De Backer L. ACS Nano. 2020 Apr 28;14(4):4774-4791. doi: 10.1021/acsnano.0c00666. Epub 2020 Apr 14. ACS Nano. 2020. PMID: 32250113
A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors.
Romero C, Lambert LJ, Sheffler DJ, De Backer LJS, Raveendra-Panickar D, Celeridad M, Grotegut S, Rodiles S, Holleran J, Sergienko E, Pasquale EB, Cosford NDP, Tautz L. Romero C, et al. Among authors: De Backer LJS. J Biol Chem. 2020 Feb 28;295(9):2601-2613. doi: 10.1074/jbc.RA119.010838. Epub 2020 Jan 17. J Biol Chem. 2020. PMID: 31953320
Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy.
Merckx P, De Backer L, Van Hoecke L, Guagliardo R, Echaide M, Baatsen P, Olmeda B, Saelens X, Pérez-Gil J, De Smedt SC, Raemdonck K. Merckx P, et al. Among authors: De Backer L. Acta Biomater. 2018 Sep 15;78:236-246. doi: 10.1016/j.actbio.2018.08.012. Epub 2018 Aug 15. Acta Biomater. 2018. PMID: 30118853
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