Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

290 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
eIF4E expression in tumors: its possible role in progression of malignancies.
De Benedetti A, Harris AL. De Benedetti A, et al. Int J Biochem Cell Biol. 1999 Jan;31(1):59-72. doi: 10.1016/s1357-2725(98)00132-0. Int J Biochem Cell Biol. 1999. PMID: 10216944 Review.
This is a strong indication that elevated eIF4E expression may mark a critical transition in cancer progression. Establishing a greater protein synthesis output may be a necessary step for cancer cells in order to sustain their rapid proliferation. How …
This is a strong indication that elevated eIF4E expression may mark a critical transition in cancer progression. Establishing …
Tissue microarray analysis of eIF4E and its downstream effector proteins in human breast cancer.
Kleiner HE, Krishnan P, Tubbs J, Smith M, Meschonat C, Shi R, Lowery-Nordberg M, Adegboyega P, Unger M, Cardelli J, Chu Q, Mathis JM, Clifford J, De Benedetti A, Li BD. Kleiner HE, et al. Among authors: de benedetti a. J Exp Clin Cancer Res. 2009 Jan 9;28(1):5. doi: 10.1186/1756-9966-28-5. J Exp Clin Cancer Res. 2009. PMID: 19134194 Free PMC article.
BACKGROUND: Eukaryotic initiation factor 4E (eIF4E) is elevated in many cancers and is a prognostic indicator in breast cancer. ...Our goal was to validate whether formalin-fixed, paraffin-embedded tissues arranged in a tissue microarray (TMA) format would be more e …
BACKGROUND: Eukaryotic initiation factor 4E (eIF4E) is elevated in many cancers and is a prognostic indicator in breast cancer. ...Ou …
eIF4E-targeted suicide gene therapy in a minimal residual mouse model for metastatic soft-tissue head and neck squamous cell carcinoma improves disease-free survival.
Siegele B, Cefalu C, Holm N, Sun G, Tubbs J, Meschonat C, Odaka Y, DeBenedetti A, Ghali GE, Chu Q, Mathis JM, Li BD. Siegele B, et al. J Surg Res. 2008 Jul;148(1):83-9. doi: 10.1016/j.jss.2008.03.011. Epub 2008 Apr 9. J Surg Res. 2008. PMID: 18570935
To exploit this dysregulation, a long 5'-untranslated region was spliced upstream of a thymidine kinase (Tk) gene to enhance translation of this "suicide" gene within cells overexpressing eIF4E. ...CONCLUSIONS: Ad-HSV-UTk suicide gene therapy prolonged disease-free …
To exploit this dysregulation, a long 5'-untranslated region was spliced upstream of a thymidine kinase (Tk) gene to enhance t …
Rat adenocarcinoma cell line infected with an adenovirus carrying a novel herpes-simplex virus-thymidine kinase suicide gene construct dies by apoptosis upon treatment with ganciclovir.
Chu QD, Sun L, Li J, Byrnes K, Chervenak D, DeBenedetti A, Mathis JM, Li BD. Chu QD, et al. J Surg Res. 2007 Nov;143(1):189-94. doi: 10.1016/j.jss.2006.12.007. J Surg Res. 2007. PMID: 17950092
Induction of apoptosis was determined using annexin V-FITC and propidium iodine detection kit and a terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling in situ cell death detection kit. ...Marked cytotoxicity was noted by the MTT assay in the infected group …
Induction of apoptosis was determined using annexin V-FITC and propidium iodine detection kit and a terminal deoxynucleotidyl transfe …
A novel suicide gene therapy targeting the overexpression of eukaryotic initiation factor 4E improves survival in a rat peritoneal carcinomatosis model.
Byrnes K, Li BD, Holm N, Li J, Okadata Y, De Benedetti A, Nedeljkovic-Kurepa A, Mathis M, Chu QD. Byrnes K, et al. Among authors: de benedetti a. Surgery. 2007 Aug;142(2):270-5. doi: 10.1016/j.surg.2007.04.009. Surgery. 2007. PMID: 17689695
We investigated the efficacy of this novel therapy in a rat peritoneal carcinomatosis (PC) model. METHODS: A PC model was developed by implanting a syngeneic 0.25 cm(3) tumor into Fisher 344 rats' omentum. ...CONCLUSIONS: Treatment with a novel suicide …
We investigated the efficacy of this novel therapy in a rat peritoneal carcinomatosis (PC) model. METHODS: A PC model was deve …
Correlation of TLK1B in elevation and recurrence in doxorubicin-treated breast cancer patients with high eIF4E overexpression.
Byrnes KW, DeBenedetti A, Holm NT, Luke J, Nunez J, Chu QD, Meschonat C, Abreo F, Johnson LW, Li BD. Byrnes KW, et al. J Am Coll Surg. 2007 May;204(5):925-33; discussion 933-4. doi: 10.1016/j.jamcollsurg.2007.02.027. J Am Coll Surg. 2007. PMID: 17481512
STUDY DESIGN: We prospectively accrued 152 patients with stage I to III breast cancer treated with a doxorubicin-based chemotherapy in an adjuvant setting. ...High TLK1B in cancer specimens was associated with a higher risk for cancer recurrence in patients treated …
STUDY DESIGN: We prospectively accrued 152 patients with stage I to III breast cancer treated with a doxorubicin-based chemotherapy i …
Up-regulation of TLK1B by eIF4E overexpression predicts cancer recurrence in irradiated patients with breast cancer.
Wolfort R, de Benedetti A, Nuthalapaty S, Yu H, Chu QD, Li BD. Wolfort R, et al. Among authors: de benedetti a. Surgery. 2006 Aug;140(2):161-9. doi: 10.1016/j.surg.2006.05.001. Surgery. 2006. PMID: 16904965
Tousled-like kinase (TLK1B) is a mammalian threonine kinase with a long 5' untranslated regions in the messenger RNA. In vitro, malignant cells with eIF4E overexpression appear to have corresponding TLK1B elevation. ...Resistance to radiotherapy may be 1 mechanism w …
Tousled-like kinase (TLK1B) is a mammalian threonine kinase with a long 5' untranslated regions in the messenger RNA. In vitro …
Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control.
Mathis JM, Williams BJ, Sibley DA, Carroll JL, Li J, Odaka Y, Barlow S, Nathan CO, Li BD, DeBenedetti A. Mathis JM, et al. J Gene Med. 2006 Sep;8(9):1105-20. doi: 10.1002/jgm.935. J Gene Med. 2006. PMID: 16802401
Real-time reverse-transcription polymerase chain reaction (RT-PCR) was used to quantify HSV-Tk mRNA for cells infected with Ad-CMV-UTk as well as with Ad-CMV-Tk (a control adenovirus in which HSV-Tk is not regulated at the level of translation). ...These results indicate t …
Real-time reverse-transcription polymerase chain reaction (RT-PCR) was used to quantify HSV-Tk mRNA for cells infected with Ad-CMV-UTk as we …
High eIF4E, VEGF, and microvessel density in stage I to III breast cancer.
Byrnes K, White S, Chu Q, Meschonat C, Yu H, Johnson LW, Debenedetti A, Abreo F, Turnage RH, McDonald JC, Li BD. Byrnes K, et al. Ann Surg. 2006 May;243(5):684-90; discussion 691-2. doi: 10.1097/01.sla.0000216770.23642.d8. Ann Surg. 2006. PMID: 16633004 Free PMC article.
OBJECTIVE: In a prospective trial, to determine if eIF4E overexpression in breast cancer specimens is correlated with VEGF elevation, increased tumor microvessel density (MVD) counts, and a worse clinical outcome irrespective of nodal status. ...METHODS: A to …
OBJECTIVE: In a prospective trial, to determine if eIF4E overexpression in breast cancer specimens is correlated with VEGF elevation, …
eIF4E as a marker for cervical neoplasia.
Matthews-Greer J, Caldito G, de Benedetti A, Herrera GA, Dominguez-Malagon H, Chanona-Vilchis J, Turbat-Herrera EA. Matthews-Greer J, et al. Among authors: de benedetti a. Appl Immunohistochem Mol Morphol. 2005 Dec;13(4):367-70. doi: 10.1097/01.pai.0000170625.98446.3e. Appl Immunohistochem Mol Morphol. 2005. PMID: 16280668
The aim of this study was to quantitate eIF4E in tissues representing a wide range of cervical pathology. The potential correlation between dysplastic grade or tumor stage with eIF4E upregulation and/or HPV genotype was analyzed for 10 normal, 27 cancer, and 37 dysplasia c …
The aim of this study was to quantitate eIF4E in tissues representing a wide range of cervical pathology. The potential correlation b …
290 results
Jump to page
Feedback