De Clercq E - Search Results

1

Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo-[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TlBO) derivatives. 4.

Ho W, Kukla MJ, Breslin HJ, Ludovici DW, Grous PP, Diamond CJ, Miranda M, Rodgers JD, Ho CY, De Clercq E, et al. Ho W, et al. Among authors: de clercq e. J Med Chem. 1995 Mar 3;38(5):794-802. doi: 10.1021/jm00005a006. J Med Chem. 1995. PMID: 7877144

2

Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-on e (TIBO) derivatives. 2.

Kukla MJ, Breslin HJ, Diamond CJ, Grous PP, Ho CY, Miranda M, Rodgers JD, Sherrill RG, De Clercq E, Pauwels R, et al. Kukla MJ, et al. Among authors: de clercq e. J Med Chem. 1991 Nov;34(11):3187-97. doi: 10.1021/jm00115a007. J Med Chem. 1991. PMID: 1956037

3

Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. Truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2( 1H)-on es (TIBO) analogues.

Breslin HJ, Kukla MJ, Kromis T, Cullis H, De Knaep F, Pauwels R, Andries K, De Clercq E, Janssen MA, Janssen PA. Breslin HJ, et al. Among authors: de clercq e, de knaep f. Bioorg Med Chem. 1999 Nov;7(11):2427-36. doi: 10.1016/s0968-0896(99)00198-4. Bioorg Med Chem. 1999. PMID: 10632052

4

Evolution of anti-HIV drug candidates. Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU).

Ludovici DW, Kukla MJ, Grous PG, Krishnan S, Andries K, de Béthune MP, Azijn H, Pauwels R, De Clercq E, Arnold E, Janssen PA. Ludovici DW, et al. Among authors: de bethune mp, de clercq e. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2225-8. doi: 10.1016/s0960-894x(01)00410-3. Bioorg Med Chem Lett. 2001. PMID: 11527703

5

New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs.

Pauwels R, Andries K, Debyser Z, Kukla MJ, Schols D, Breslin HJ, Woestenborghs R, Desmyter J, Janssen MA, De Clercq E, et al. Pauwels R, et al. Among authors: de clercq e. Antimicrob Agents Chemother. 1994 Dec;38(12):2863-70. doi: 10.1128/AAC.38.12.2863. Antimicrob Agents Chemother. 1994. PMID: 7535037 Free PMC article.

6

An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives.

Debyser Z, Pauwels R, Andries K, Desmyter J, Kukla M, Janssen PA, De Clercq E. Debyser Z, et al. Among authors: de clercq e. Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1451-5. doi: 10.1073/pnas.88.4.1451. Proc Natl Acad Sci U S A. 1991. PMID: 1705038 Free PMC article.

7

TIBO derivatives: a new class of highly potent and specific inhibitors of HIV-1 replication.

Pauwels R, Andries K, Debyser Z, Kukla M, Schols D, Desmyter J, De Clercq E, Janssen PA. Pauwels R, et al. Among authors: de clercq e. Biochem Soc Trans. 1992 May;20(2):509-12. doi: 10.1042/bst0200509. Biochem Soc Trans. 1992. PMID: 1383063 Review. No abstract available.

8

Novel series of TSAO-T derivatives. Synthesis and anti-HIV-1 activity of 4-, 5-, and 6-substituted pyrimidine analogues.

San-Félix A, Velázquez S, Pérez-Pérez MJ, Balzarini J, De Clercq E, Camarasa MJ. San-Félix A, et al. Among authors: de clercq e. J Med Chem. 1994 Feb 18;37(4):453-60. doi: 10.1021/jm00030a004. J Med Chem. 1994. PMID: 7509877

9

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication. 2. Effect of heteroaromatic linkers on the activity of bicyclams.

Bridger GJ, Skerlj RT, Padmanabhan S, Martellucci SA, Henson GW, Abrams MJ, Joao HC, Witvrouw M, De Vreese K, Pauwels R, De Clercq E. Bridger GJ, et al. Among authors: de vreese k, de clercq e. J Med Chem. 1996 Jan 5;39(1):109-19. doi: 10.1021/jm950584t. J Med Chem. 1996. PMID: 8568797

10

Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity.

Tanaka H, Takashima H, Ubasawa M, Sekiya K, Nitta I, Baba M, Shigeta S, Walker RT, De Clercq E, Miyasaka T. Tanaka H, et al. Among authors: de clercq e. J Med Chem. 1992 Jan 24;35(2):337-45. doi: 10.1021/jm00080a020. J Med Chem. 1992. PMID: 1732552

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