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Carnitine increases glucose disposal in humans.
De Gaetano A, Mingrone G, Castagneto M, Calvani M. De Gaetano A, et al. J Am Coll Nutr. 1999 Aug;18(4):289-95. doi: 10.1080/07315724.1999.10718866. J Am Coll Nutr. 1999. PMID: 12038470
METHODS: Fourteen healthy human volunteers were subjected to the intravenous glucose tolerance test (analyzed by means of the minimal model technique), together with indirect calorimetry and measurement of serum free fatty acids, after a bolus of glucose plus carnitine (C) …
METHODS: Fourteen healthy human volunteers were subjected to the intravenous glucose tolerance test (analyzed by means of the minimal model …
Tracer study of metabolism and tissue distribution of sebacic acid in rats.
Tataranni PA, Mingrone G, De Gaetano A, Raguso C, Greco AV. Tataranni PA, et al. Ann Nutr Metab. 1992;36(5-6):296-303. doi: 10.1159/000177733. Ann Nutr Metab. 1992. PMID: 1492757
Metabolic effects and disposition of sebacate, an alternate dicarboxylic fuel substrate.
Greco AV, Mingrone G, Raguso C, Tataranni A, Finotti E, Tacchino RM, Capristo E, De Gaetano A, Castagneto M. Greco AV, et al. Ann Nutr Metab. 1992;36(1):1-11. doi: 10.1159/000177693. Ann Nutr Metab. 1992. PMID: 1590667
Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. We investigated its pharmacokinetic profile and thermogenic effect during a short-time infusion (5 h at 10 g/h) in 7 male volunteers. ...A single-compartm …
Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. We investigated its pharmaco …
Effects of dexfenfluramine on free fatty acid turnover and oxidation in obese patients with type 2 diabetes mellitus.
Greco AV, Mingrone G, Capristo E, De Gaetano A, Ghirlanda G, Castagneto M. Greco AV, et al. Metabolism. 1995 Feb;44(2 Suppl 2):57-61. doi: 10.1016/0026-0495(95)90212-0. Metabolism. 1995. PMID: 7869940 Clinical Trial.
Gas exchange was measured both basally and during a ventilated-hood system, indirect-calorimetry session. The protocol was a randomized, placebo-controlled, single-blind design. Subjects received dF 30 mg acutely (n = 6) or a placebo (n = 5). A dose of …
Gas exchange was measured both basally and during a ventilated-hood system, indirect-calorimetry session. The protocol was a r …
Pharmacokinetic profile of dodecanedioic acid, a proposed alternative fuel substrate.
Mingrone G, Greco AV, De Gaetano A, Tataranni A, Raguso C, Castagneto M. Mingrone G, et al. JPEN J Parenter Enteral Nutr. 1994 May-Jun;18(3):225-30. doi: 10.1177/0148607194018003225. JPEN J Parenter Enteral Nutr. 1994. PMID: 8064997
Dodecanedioic acid (C12), a saturated, aliphatic dicarboxylic acid with 12 carbon atoms, was given as an intravenous bolus (800 mumol/kg of body weight [kgBW]) in male Wistar rats to study its pharmacokinetic profile. ...Only a single binding site was clearly identi …
Dodecanedioic acid (C12), a saturated, aliphatic dicarboxylic acid with 12 carbon atoms, was given as an intravenous bolus (800 mumol …
Glucose-induced thermogenesis in postobese women who have undergone biliopancreatic diversion.
Tataranni PA, Mingrone G, Greco AV, Caradonna P, Capristo E, Raguso CA, De Gaetano A, Tacchino RM, Castagneto M. Tataranni PA, et al. Am J Clin Nutr. 1994 Sep;60(3):320-6. doi: 10.1093/ajcn/60.3.320. Am J Clin Nutr. 1994. PMID: 8074060
We evaluated the metabolic response to a standard (75-g) oral-glucose-tolerance test (OGTT) in eight post-obese women (PO) who underwent biliopancreatic diversion and in eight healthy control women (C). ...These data indicate that GIT and insulin-glucose metabolism are not …
We evaluated the metabolic response to a standard (75-g) oral-glucose-tolerance test (OGTT) in eight post-obese women (PO) who underw …
Dicarboxylic acids and glucose utilization in humans: effect of sebacate.
Raguso CA, Mingrone G, Greco AV, Tataranni PA, De Gaetano A, Castagneto M. Raguso CA, et al. JPEN J Parenter Enteral Nutr. 1994 Jan-Feb;18(1):9-13. doi: 10.1177/014860719401800109. JPEN J Parenter Enteral Nutr. 1994. PMID: 8164314 Clinical Trial.
All subjects received a constant 5-hour infusion of saline or sebacate (6.6 g/h), in a randomized order on two different days. ...In conclusion, Sb administration was associated with a glucose-sparing effect as shown by the reduced glucose uptake in all patie …
All subjects received a constant 5-hour infusion of saline or sebacate (6.6 g/h), in a randomized order on two different days. …
PC-based differential model fitting as a support for clinical research.
De Gaetano A, Castagneto M, Mingrone G, Coleman WP, Sganga G, Tataranni PA, Gangeri G, Greco AV. De Gaetano A, et al. Int J Clin Monit Comput. 1994 Feb;11(1):35-41. doi: 10.1007/BF01132842. Int J Clin Monit Comput. 1994. PMID: 8195657
A PC-based minimisation software written in C-language is described, which solves numerically both simple non-linear regression problems and problems expressed as systems of (unsolved) initial-value ordinary or partial differential equations. ...A real test problem
A PC-based minimisation software written in C-language is described, which solves numerically both simple non-linear regression probl
Kinetics of medium-chain triglycerides and free fatty acids in healthy volunteers and surgically stressed patients.
De Gaetano A, Castagneto M, Mingrone G, Gangeri G, Sganga G, Tataranni PA, Raguso C, Greco AV. De Gaetano A, et al. JPEN J Parenter Enteral Nutr. 1994 Mar-Apr;18(2):134-40. doi: 10.1177/0148607194018002134. JPEN J Parenter Enteral Nutr. 1994. PMID: 8201748
A linear two-compartment model was found to be descriptive and robust: the apparent volumes of distribution were found to be similar in healthy and surgical subjects for both MCTs and MCFAs. ...
A linear two-compartment model was found to be descriptive and robust: the apparent volumes of distribution were found to be similar
Turnover and oxidation rates of plasma-free fatty acids in obese patients treated with dexfenfluramine.
Greco AV, Mingrone G, Tataranni PA, Raguso C, De Gaetano A, Tacchino RM, Lavielle R, Ghirlanda G. Greco AV, et al. Ann Nutr Metab. 1993;37(5):237-44. doi: 10.1159/000177773. Ann Nutr Metab. 1993. PMID: 8311417
In order to assess a possible direct metabolic effect of dexfenfluramine (dF) apart from its action on food intake reduction, 10 obese postmenopausal women and 10 obese men (BMI = 32.19 +/- 1.99 kg/m2) were studied in a single-blind fashion: 4 weeks on placebo (D-28 …
In order to assess a possible direct metabolic effect of dexfenfluramine (dF) apart from its action on food intake reduction, 10 obes …
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