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Interferon/STAT1 and neuregulin signaling pathways are exploratory biomarkers of cetuximab (Erbitux®) efficacy in KRAS wild-type squamous carcinomas: a pathway-based analysis of whole human-genome microarray data from cetuximab-adapted tumor cell-line models.
Oliveras-Ferraros C, Vazquez-Martin A, Queralt B, Adrados M, Ortiz R, Cufí S, Hernández-Yagüe X, Guardeño R, Báez L, Martin-Castillo B, Pérez-Martínez MC, Lopez-Bonet E, De Llorens R, Bernadó L, Brunet J, Menendez JA. Oliveras-Ferraros C, et al. Among authors: de llorens r. Int J Oncol. 2011 Dec;39(6):1455-79. doi: 10.3892/ijo.2011.1155. Epub 2011 Aug 9. Int J Oncol. 2011. PMID: 21833472
Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells.
Oliveras-Ferraros C, Cufí S, Queralt B, Vazquez-Martin A, Martin-Castillo B, de Llorens R, Bosch-Barrera J, Brunet J, Menendez JA. Oliveras-Ferraros C, et al. Among authors: de llorens r. Br J Cancer. 2012 Apr 10;106(8):1406-14. doi: 10.1038/bjc.2012.103. Br J Cancer. 2012. PMID: 22491422 Free PMC article.
Evolution of the predictive markers amphiregulin and epiregulin mRNAs during long-term cetuximab treatment of KRAS wild-type tumor cells.
Oliveras-Ferraros C, Massaguer Vall-Llovera A, Carrion Salip D, Vazquez-Martin A, Cufí S, Queralt B, Martin-Castillo B, Brunet J, de Llorens R, Menendez JA. Oliveras-Ferraros C, et al. Among authors: de llorens r. Invest New Drugs. 2012 Apr;30(2):846-52. doi: 10.1007/s10637-010-9612-2. Epub 2010 Dec 16. Invest New Drugs. 2012. PMID: 21161326
Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment.
Oliveras-Ferraros C, Massaguer Vall-Llovera A, Vazquez-Martin A, Salip DC, Queralt B, Cufí S, Martin-Castillo B, Bosch-Barrera J, Brunet J, De Llorens R, Menendez JA. Oliveras-Ferraros C, et al. Among authors: de llorens r. Oncol Rep. 2012 Jun;27(6):1887-92. doi: 10.3892/or.2012.1732. Epub 2012 Mar 15. Oncol Rep. 2012. PMID: 22427198
Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.
Cuyàs E, Fernández-Arroyo S, Corominas-Faja B, Rodríguez-Gallego E, Bosch-Barrera J, Martin-Castillo B, De Llorens R, Joven J, Menendez JA. Cuyàs E, et al. Among authors: de llorens r. Oncotarget. 2015 May 20;6(14):12279-96. doi: 10.18632/oncotarget.3733. Oncotarget. 2015. PMID: 25980580 Free PMC article.
A comparison of non-biologically active truncated EGF (EGFt) and full-length hEGF for delivery of Auger electron-emitting 111In to EGFR-positive breast cancer cells and tumor xenografts in athymic mice.
Panosa C, Fonge H, Ferrer-Batallé M, Menéndez JA, Massaguer A, De Llorens R, Reilly RM. Panosa C, et al. Among authors: de llorens r. Nucl Med Biol. 2015 Dec;42(12):931-8. doi: 10.1016/j.nucmedbio.2015.08.003. Epub 2015 Aug 19. Nucl Med Biol. 2015. PMID: 26385534
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