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A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.
Turro E, Greene D, Wijgaerts A, Thys C, Lentaigne C, Bariana TK, Westbury SK, Kelly AM, Selleslag D, Stephens JC, Papadia S, Simeoni I, Penkett CJ, Ashford S, Attwood A, Austin S, Bakchoul T, Collins P, Deevi SV, Favier R, Kostadima M, Lambert MP, Mathias M, Millar CM, Peerlinck K, Perry DJ, Schulman S, Whitehorn D, Wittevrongel C; BRIDGE-BPD Consortium; De Maeyer M, Rendon A, Gomez K, Erber WN, Mumford AD, Nurden P, Stirrups K, Bradley JR, Raymond FL, Laffan MA, Van Geet C, Richardson S, Freson K, Ouwehand WH. Turro E, et al. Among authors: de maeyer m. Sci Transl Med. 2016 Mar 2;8(328):328ra30. doi: 10.1126/scitranslmed.aad7666. Epub 2016 Mar 2. Sci Transl Med. 2016. PMID: 26936507 Free PMC article.
Molecular mechanisms of mild and moderate hemophilia A.
Jacquemin M, De Maeyer M, D'Oiron R, Lavend'Homme R, Peerlinck K, Saint-Remy JM. Jacquemin M, et al. Among authors: de maeyer m. J Thromb Haemost. 2003 Mar;1(3):456-63. doi: 10.1046/j.1538-7836.2003.00088.x. J Thromb Haemost. 2003. PMID: 12871450 Free article. Review.
Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump.
Vandecaetsbeek I, Trekels M, De Maeyer M, Ceulemans H, Lescrinier E, Raeymaekers L, Wuytack F, Vangheluwe P. Vandecaetsbeek I, et al. Among authors: de maeyer m. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18533-8. doi: 10.1073/pnas.0906797106. Epub 2009 Oct 21. Proc Natl Acad Sci U S A. 2009. PMID: 19846779 Free PMC article.
In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.
Vancraenenbroeck R, De Raeymaecker J, Lobbestael E, Gao F, De Maeyer M, Voet A, Baekelandt V, Taymans JM. Vancraenenbroeck R, et al. Among authors: de raeymaecker j, de maeyer m. Front Mol Neurosci. 2014 Jun 3;7:51. doi: 10.3389/fnmol.2014.00051. eCollection 2014. Front Mol Neurosci. 2014. PMID: 24917786 Free PMC article.
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.
Daniëls V, Vancraenenbroeck R, Law BM, Greggio E, Lobbestael E, Gao F, De Maeyer M, Cookson MR, Harvey K, Baekelandt V, Taymans JM. Daniëls V, et al. Among authors: de maeyer m. J Neurochem. 2011 Jan;116(2):304-15. doi: 10.1111/j.1471-4159.2010.07105.x. J Neurochem. 2011. PMID: 21073465 Free PMC article.
Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain.
Staelens S, Hadders MA, Vauterin S, Platteau C, De Maeyer M, Vanhoorelbeke K, Huizinga EG, Deckmyn H. Staelens S, et al. Among authors: de maeyer m. J Biol Chem. 2006 Jan 27;281(4):2225-31. doi: 10.1074/jbc.M508191200. Epub 2005 Nov 28. J Biol Chem. 2006. PMID: 16314412 Free article.
The antithrombotic monoclonal antibody 82D6A3 is directed against amino acids Arg-963, Pro-981, Asp-1009, Arg-1016, Ser-1020, Met-1022, and His-1023 of the von Willebrand factor A3-domain (Vanhoorelbeke, K., Depraetere, H., Romijn, R. A., Huizinga, E., De Maeyer, …
The antithrombotic monoclonal antibody 82D6A3 is directed against amino acids Arg-963, Pro-981, Asp-1009, Arg-1016, Ser-1020, Met-1022, and …
196 results