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A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes.
Cavrois M, De Noronha C, Greene WC. Cavrois M, et al. Among authors: de noronha c. Nat Biotechnol. 2002 Nov;20(11):1151-4. doi: 10.1038/nbt745. Epub 2002 Sep 30. Nat Biotechnol. 2002. PMID: 12355096
Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement.
Fenard D, Yonemoto W, de Noronha C, Cavrois M, Williams SA, Greene WC. Fenard D, et al. Among authors: de noronha c. J Immunol. 2005 Nov 1;175(9):6050-7. doi: 10.4049/jimmunol.175.9.6050. J Immunol. 2005. PMID: 16237100
This Nef-induced priming of TCR signaling pathways occurred independently of calcium signaling and involved a very proximal step before protein kinase C activation. ...
This Nef-induced priming of TCR signaling pathways occurred independently of calcium signaling and involved a very proximal step before prot …
HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability.
Stopak K, de Noronha C, Yonemoto W, Greene WC. Stopak K, et al. Among authors: de noronha c. Mol Cell. 2003 Sep;12(3):591-601. doi: 10.1016/s1097-2765(03)00353-8. Mol Cell. 2003. PMID: 14527406
Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo.
Zimmerman ES, Sherman MP, Blackett JL, Neidleman JA, Kreis C, Mundt P, Williams SA, Warmerdam M, Kahn J, Hecht FM, Grant RM, de Noronha CM, Weyrich AS, Greene WC, Planelles V. Zimmerman ES, et al. Among authors: de noronha cm. J Virol. 2006 Nov;80(21):10407-18. doi: 10.1128/JVI.01212-06. Epub 2006 Sep 6. J Virol. 2006. PMID: 16956949 Free PMC article.
Nuclear export of Vpr is required for efficient replication of human immunodeficiency virus type 1 in tissue macrophages.
Sherman MP, de Noronha CM, Eckstein LA, Hataye J, Mundt P, Williams SA, Neidleman JA, Goldsmith MA, Greene WC. Sherman MP, et al. Among authors: de noronha cm. J Virol. 2003 Jul;77(13):7582-9. doi: 10.1128/jvi.77.13.7582-7589.2003. J Virol. 2003. PMID: 12805458 Free PMC article.
Insights into the biology of HIV-1 viral protein R.
Sherman MP, De Noronha CM, Williams SA, Greene WC. Sherman MP, et al. Among authors: de noronha cm. DNA Cell Biol. 2002 Sep;21(9):679-88. doi: 10.1089/104454902760330228. DNA Cell Biol. 2002. PMID: 12396611 Review.
HIV-1 Vpr displays natural protein-transducing properties: implications for viral pathogenesis.
Sherman MP, Schubert U, Williams SA, de Noronha CM, Kreisberg JF, Henklein P, Greene WC. Sherman MP, et al. Among authors: de noronha cm. Virology. 2002 Oct 10;302(1):95-105. doi: 10.1006/viro.2002.1576. Virology. 2002. PMID: 12429519
HIV-1 Vpr enhances viral burden by facilitating infection of tissue macrophages but not nondividing CD4+ T cells.
Eckstein DA, Sherman MP, Penn ML, Chin PS, De Noronha CM, Greene WC, Goldsmith MA. Eckstein DA, et al. Among authors: de noronha cm. J Exp Med. 2001 Nov 19;194(10):1407-19. doi: 10.1084/jem.194.10.1407. J Exp Med. 2001. PMID: 11714748 Free PMC article.
Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr.
de Noronha CM, Sherman MP, Lin HW, Cavrois MV, Moir RD, Goldman RD, Greene WC. de Noronha CM, et al. Science. 2001 Nov 2;294(5544):1105-8. doi: 10.1126/science.1063957. Science. 2001. PMID: 11691994
Nucleocytoplasmic shuttling by human immunodeficiency virus type 1 Vpr.
Sherman MP, de Noronha CM, Heusch MI, Greene S, Greene WC. Sherman MP, et al. Among authors: de noronha cm. J Virol. 2001 Feb;75(3):1522-32. doi: 10.1128/JVI.75.3.1522-1532.2001. J Virol. 2001. PMID: 11152524 Free PMC article.
Surprisingly, when the leucine-rich Vpr(1-71) fragment, previously shown to harbor an NLS, or full-length Vpr is fused to the C terminus of a green fluorescent protein-pyruvate kinase (GFP-PK) chimera, the resultant protein is almost exclusively detected in the cytoplasm. …
Surprisingly, when the leucine-rich Vpr(1-71) fragment, previously shown to harbor an NLS, or full-length Vpr is fused to the C termi …
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