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Virtual reality operating room with AI guidance: design and validation of a fire scenario
Qi D, et al. Surg Endosc 2020. Among authors: De S. PMID 32072293
The simulator can predict the user's actions in the virtual OR and provide them with timely feedback to assist with training. ...A Friedman's ANOVA with post hoc tests was used to evaluate the effect of multiple trials on performance. RESULTS: On a 7-point scale, eight of the ten questions were rated a mean of 6 or greater (72.73%), especially those relating to the usefulness of the simulator for OR fire-containing training. 79.25% of the participants rated the degree of usefulness of AI guidance over 6 out of 7. ...
The simulator can predict the user's actions in the virtual OR and provide them with timely feedback to assist with training. ...A Fr …
A circular RNA from the MDM2 locus controls cell cycle progression by suppressing p53 levels
Chaudhary R, et al. Mol Cell Biol 2020. Among authors: De S. PMID 32041821
Given the central role of MDM2 in suppressing p53 protein levels and p53 activity, we investigated the function of circ-MDM2 Knocking down circ-MDM2 with siRNAs that targeted circ-MDM2, did not alter MDM2 mRNA or MDM2 protein levels, but resulted in increased basal p53 levels and growth defects in vitro and in vivo Consistent with these results, transcriptome profiling showed increased expression of several direct p53 targets, reduced Rb phosphorylation and defects in G1-S progression upon silencing circ-MDM2 Our results on the initial characterization of circ-MDM2, identify a new player from the MDM2 locus that suppresses p53 levels and cell cycle progression....
Given the central role of MDM2 in suppressing p53 protein levels and p53 activity, we investigated the function of circ-MDM2 Knocking down c …
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