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M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity.
De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL. De Souza AT, et al. Nat Genet. 1995 Dec;11(4):447-9. doi: 10.1038/ng1295-447. Nat Genet. 1995. PMID: 7493029
We have recently shown that 70% of human hepatocellular tumours have loss of heterozygosity (LOH) at the M6P/IGF2R locus which maps to chromosome 6q26-q27 (ref. 8). ...
We have recently shown that 70% of human hepatocellular tumours have loss of heterozygosity (LOH) at the M6P/IGF2R locus which maps t …
M6P/IGF2 receptor: a candidate breast tumor suppressor gene.
Hankins GR, De Souza AT, Bentley RC, Patel MR, Marks JR, Iglehart JD, Jirtle RL. Hankins GR, et al. Among authors: de souza at. Oncogene. 1996 May 2;12(9):2003-9. Oncogene. 1996. PMID: 8649861
We have found its expression to be significantly reduced in both rat and human hepatocellular carcinomas (HCCs) and recently reported loss of heterozygosity (LOH) at this locus with mutations in the remaining allele in human liver tumors. ...
We have found its expression to be significantly reduced in both rat and human hepatocellular carcinomas (HCCs) and recently reported loss o …
Imprinted M6p/Igf2 receptor is mutated in rat liver tumors.
Mills JJ, Falls JG, De Souza AT, Jirtle RL. Mills JJ, et al. Among authors: de souza at. Oncogene. 1998 May 28;16(21):2797-802. doi: 10.1038/sj.onc.1201801. Oncogene. 1998. PMID: 9652747
Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis.
Yamada T, De Souza AT, Finkelstein S, Jirtle RL. Yamada T, et al. Among authors: de souza at. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10351-5. doi: 10.1073/pnas.94.19.10351. Proc Natl Acad Sci U S A. 1997. PMID: 9294214 Free PMC article.
This report shows that loss of heterozygosity at the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) locus occurred in 5/8 (63%) dysplastic liver lesions and 11/18 (61%) hepatocellular carcinomas (HCCs) associated with the high risk factors of hepati …
This report shows that loss of heterozygosity at the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) locus occ …
Imprinted genes in liver carcinogenesis.
De Souza AT, Yamada T, Mills JJ, Jirtle RL. De Souza AT, et al. FASEB J. 1997 Jan;11(1):60-7. doi: 10.1096/fasebj.11.1.9034167. FASEB J. 1997. PMID: 9034167 Review.
Recently, a high frequency of loss of heterozygosity with concomitant mutations in the remaining allele has been shown to occur at the M6P/IGF2R locus (i.e., 6q26-q27) in both human liver and breast tumors, suggesting that this gene functions as a tumor suppressor. ...
Recently, a high frequency of loss of heterozygosity with concomitant mutations in the remaining allele has been shown to occur at th …
Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors.
De Souza AT, Hankins GR, Washington MK, Fine RL, Orton TC, Jirtle RL. De Souza AT, et al. Oncogene. 1995 May 4;10(9):1725-9. Oncogene. 1995. PMID: 7753549
This is the first report of LOH at the M6P/IGFIIr locus in human hepatocellular tumors, and the presence of LOH in adenomas suggests that allelic loss may be an early event in the etiology of HCCs. ...
This is the first report of LOH at the M6P/IGFIIr locus in human hepatocellular tumors, and the presence of LOH in adenomas suggests …
Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers.
Devi GR, De Souza AT, Byrd JC, Jirtle RL, MacDonald RG. Devi GR, et al. Among authors: de souza at. Cancer Res. 1999 Sep 1;59(17):4314-9. Cancer Res. 1999. PMID: 10485478
Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations.
Byrd JC, Devi GR, de Souza AT, Jirtle RL, MacDonald RG. Byrd JC, et al. Among authors: de souza at. J Biol Chem. 1999 Aug 20;274(34):24408-16. doi: 10.1074/jbc.274.34.24408. J Biol Chem. 1999. PMID: 10446221
Ozonation of cassava starch to produce biodegradable films.
La Fuente CIA, de Souza AT, Tadini CC, Augusto PED. La Fuente CIA, et al. Among authors: de souza at. Int J Biol Macromol. 2019 Dec 1;141:713-720. doi: 10.1016/j.ijbiomac.2019.09.028. Epub 2019 Sep 5. Int J Biol Macromol. 2019. PMID: 31494157
Comparative transcriptome analysis reveals different strategies for degradation of steam-exploded sugarcane bagasse by Aspergillus niger and Trichoderma reesei.
Borin GP, Sanchez CC, de Santana ES, Zanini GK, Dos Santos RAC, de Oliveira Pontes A, de Souza AT, Dal'Mas RMMTS, Riaño-Pachón DM, Goldman GH, Oliveira JVC. Borin GP, et al. Among authors: de souza at. BMC Genomics. 2017 Jun 30;18(1):501. doi: 10.1186/s12864-017-3857-5. BMC Genomics. 2017. PMID: 28666414 Free PMC article.
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