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Oxidative phosphorylation defect in the brains of carriers of the tRNAleu(UUR) A3243G mutation in a MELAS pedigree.
Dubeau F, De Stefano N, Zifkin BG, Arnold DL, Shoubridge EA. Dubeau F, et al. Among authors: de stefano n. Ann Neurol. 2000 Feb;47(2):179-85. Ann Neurol. 2000. PMID: 10665488
Efficacy of subcutaneous interferon β-1a on MRI outcomes in a randomised controlled trial of patients with clinically isolated syndromes.
De Stefano N, Comi G, Kappos L, Freedman MS, Polman CH, Uitdehaag BM, Hennessy B, Casset-Semanaz F, Lehr L, Stubinski B, Jack DL, Barkhof F. De Stefano N, et al. J Neurol Neurosurg Psychiatry. 2014 Jun;85(6):647-53. doi: 10.1136/jnnp-2013-306289. Epub 2013 Nov 29. J Neurol Neurosurg Psychiatry. 2014. PMID: 24292999 Free PMC article. Clinical Trial.
RESULTS: 517 patients were randomised (intent-to-treat population: subcutaneous IFN β-1a three times a week, n=171; subcutaneous IFN β-1a once a week, n=175; placebo, n=171). ...
RESULTS: 517 patients were randomised (intent-to-treat population: subcutaneous IFN β-1a three times a week, n=171; subcutaneous IFN …
Location of brain lesions predicts conversion of clinically isolated syndromes to multiple sclerosis.
Giorgio A, Battaglini M, Rocca MA, De Leucio A, Absinta M, van Schijndel R, Rovira A, Tintoré M, Chard D, Ciccarelli O, Enzinger C, Gasperini C, Frederiksen J, Filippi M, Barkhof F, De Stefano N; MAGNIMS Study Group. Giorgio A, et al. Among authors: de leucio a, de stefano n. Neurology. 2013 Jan 15;80(3):234-41. doi: 10.1212/WNL.0b013e31827debeb. Epub 2012 Dec 5. Neurology. 2013. PMID: 23223533
Brain metabolic changes suggestive of axonal damage in radiologically isolated syndrome.
Stromillo ML, Giorgio A, Rossi F, Battaglini M, Hakiki B, Malentacchi G, Santangelo M, Gasperini C, Bartolozzi ML, Portaccio E, Amato MP, De Stefano N. Stromillo ML, et al. Among authors: de stefano n. Neurology. 2013 Jun 4;80(23):2090-4. doi: 10.1212/WNL.0b013e318295d707. Epub 2013 May 1. Neurology. 2013. PMID: 23635962
METHODS: Twenty-three RIS subjects who were classified according to the Okuda Criteria underwent 1H-MRSI examination with a central brain (CB) volume of interest (VOI) to measure levels of N-acetylaspartate (NAA) and choline (Cho) normalized to creatine (Cr) in the whole C …
METHODS: Twenty-three RIS subjects who were classified according to the Okuda Criteria underwent 1H-MRSI examination with a central brain (C …
Optimizing treatment success in multiple sclerosis.
Ziemssen T, Derfuss T, de Stefano N, Giovannoni G, Palavra F, Tomic D, Vollmer T, Schippling S. Ziemssen T, et al. Among authors: de stefano n. J Neurol. 2016 Jun;263(6):1053-65. doi: 10.1007/s00415-015-7986-y. Epub 2015 Dec 24. J Neurol. 2016. PMID: 26705122 Free PMC article. Review.
Cortical damage in brains of patients with adult-form of myotonic dystrophy type 1 and no or minimal MRI abnormalities.
Giorgio A, Dotti MT, Battaglini M, Marino S, Mortilla M, Stromillo ML, Bramanti P, Orrico A, Federico A, De Stefano N. Giorgio A, et al. Among authors: de stefano n. J Neurol. 2006 Nov;253(11):1471-7. doi: 10.1007/s00415-006-0248-2. Epub 2006 Jun 19. J Neurol. 2006. PMID: 16786209
Diffuse structural and metabolic brain changes in Fabry disease.
Marino S, Borsini W, Buchner S, Mortilla M, Stromillo ML, Battaglini M, Giorgio A, Bramanti P, Federico A, De Stefano N. Marino S, et al. Among authors: de stefano n. J Neurol. 2006 Apr;253(4):434-40. doi: 10.1007/s00415-005-0020-z. Epub 2006 Mar 20. J Neurol. 2006. PMID: 16541218
Each subject underwent brain proton MRI/MR spectroscopic imaging (MRSI) examinations to obtain measures of total brain volumes, total brain lesion volumes, magnetization transfer ratios (MTr) in WM and central brain levels of N-acetylaspartate (NAA) to creatine (Cr). ...
Each subject underwent brain proton MRI/MR spectroscopic imaging (MRSI) examinations to obtain measures of total brain volumes, total brain …
Brain mitochondrial impairment in ethylmalonic encephalopathy.
Grosso S, Balestri P, Mostardini R, Federico A, De Stefano N. Grosso S, et al. Among authors: de stefano n. J Neurol. 2004 Jun;251(6):755-6. doi: 10.1007/s00415-004-0426-z. J Neurol. 2004. PMID: 15311356 No abstract available.
Imaging brain damage in first-degree relatives of sporadic and familial multiple sclerosis.
De Stefano N, Cocco E, Lai M, Battaglini M, Spissu A, Marchi P, Floris G, Mortilla M, Stromillo ML, Paolillo A, Federico A, Marrosu MG. De Stefano N, et al. Ann Neurol. 2006 Apr;59(4):634-9. doi: 10.1002/ana.20767. Ann Neurol. 2006. PMID: 16498621
METHODS: Asymptomatic first-degree relatives of sporadic (sMS, n = 152) and familial MS (fMS, n = 88) and healthy volunteers (NC, n = 56) underwent brain MRI and magnetization transfer (MT) imaging on a mobile MR scan. ...
METHODS: Asymptomatic first-degree relatives of sporadic (sMS, n = 152) and familial MS (fMS, n = 88) and healthy volunteers ( …
A case of ovarioleukodystrophy without eIF2B mutations.
Gaudiano C, Di Perri C, Scali O, Rufa A, Battisti C, De Stefano N, Federico A. Gaudiano C, et al. Among authors: de stefano n. J Neurol Sci. 2008 May 15;268(1-2):183-6. doi: 10.1016/j.jns.2007.10.027. Epub 2007 Dec 3. J Neurol Sci. 2008. PMID: 18061208
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