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A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.
Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. Leissring MA, et al. Among authors: de strooper b. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4697-702. doi: 10.1073/pnas.072033799. Epub 2002 Mar 26. Proc Natl Acad Sci U S A. 2002. PMID: 11917117 Free PMC article.
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.
Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, Shearman M, Kopan R. Schroeter EH, et al. Among authors: de strooper b. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13075-80. doi: 10.1073/pnas.1735338100. Epub 2003 Oct 17. Proc Natl Acad Sci U S A. 2003. PMID: 14566063 Free PMC article.
Presenilin function in APP processing.
Annaert W, Cupers P, Saftig P, De Strooper B. Annaert W, et al. Among authors: de strooper b. Ann N Y Acad Sci. 2000;920:158-64. doi: 10.1111/j.1749-6632.2000.tb06917.x. Ann N Y Acad Sci. 2000. PMID: 11193144 Review.
Active gamma-secretase complexes contain only one of each component.
Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Sato T, et al. Among authors: de strooper b. J Biol Chem. 2007 Nov 23;282(47):33985-93. doi: 10.1074/jbc.M705248200. Epub 2007 Oct 2. J Biol Chem. 2007. PMID: 17911105 Free article.
Implication of APP secretases in notch signaling.
Hartmann D, Tournoy J, Saftig P, Annaert W, De Strooper B. Hartmann D, et al. Among authors: de strooper b. J Mol Neurosci. 2001 Oct;17(2):171-81. doi: 10.1385/JMN:17:2:171. J Mol Neurosci. 2001. PMID: 11816790 Review.
394 results