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347 results
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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics.
Karran E, Mercken M, De Strooper B. Karran E, et al. Among authors: de strooper b. Nat Rev Drug Discov. 2011 Aug 19;10(9):698-712. doi: 10.1038/nrd3505. Nat Rev Drug Discov. 2011. PMID: 21852788 Review.
Amyloid precursor protein accumulation in Lewy body dementia and Alzheimer's disease.
Van Gool D, De Strooper B, Van Leuven F, Dom R. Van Gool D, et al. Among authors: de strooper b. Dementia. 1995 Mar-Apr;6(2):63-8. doi: 10.1159/000106923. Dementia. 1995. PMID: 7606281
alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease.
Van Gool D, De Strooper B, Van Leuven F, Triau E, Dom R. Van Gool D, et al. Among authors: de strooper b. Neurobiol Aging. 1993 May-Jun;14(3):233-7. doi: 10.1016/0197-4580(93)90006-w. Neurobiol Aging. 1993. PMID: 7686641
Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease.
De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B, Van Leuven F, Van den Berghe H. De Strooper B, et al. J Biol Chem. 1995 Feb 24;270(8):4058-65. doi: 10.1074/jbc.270.8.4058. J Biol Chem. 1995. PMID: 7876155
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. De Strooper B, et al. Nature. 1998 Jan 22;391(6665):387-90. doi: 10.1038/34910. Nature. 1998. PMID: 9450754
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis.
Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA. Zhang Z, et al. Among authors: de strooper b. Nature. 1998 Oct 15;395(6703):698-702. doi: 10.1038/27208. Nature. 1998. PMID: 9790190
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. De Strooper B, et al. Nature. 1999 Apr 8;398(6727):518-22. doi: 10.1038/19083. Nature. 1999. PMID: 10206645
Alzheimer's disease. A firm base for drug development.
De Strooper B, K├Ânig G. De Strooper B, et al. Nature. 1999 Dec 2;402(6761):471-2. doi: 10.1038/44973. Nature. 1999. PMID: 10591201 No abstract available.
Proteolytic processing and cell biological functions of the amyloid precursor protein.
De Strooper B, Annaert W. De Strooper B, et al. J Cell Sci. 2000 Jun;113 ( Pt 11):1857-70. J Cell Sci. 2000. PMID: 10806097 Review.
Alzheimer's disease. Closing in on gamma-secretase.
De Strooper B. De Strooper B. Nature. 2000 Jun 8;405(6787):627, 629. doi: 10.1038/35015193. Nature. 2000. PMID: 10864307 No abstract available.
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