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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.
Benilova I, Karran E, De Strooper B. Benilova I, et al. Nat Neurosci. 2012 Jan 29;15(3):349-57. doi: 10.1038/nn.3028. Nat Neurosci. 2012. PMID: 22286176 Review.
The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported.
De Strooper B, Van Leuven F, Van den Berghe H. De Strooper B, et al. Biochim Biophys Acta. 1991 Dec 2;1129(1):141-3. doi: 10.1016/0167-4781(91)90231-a. Biochim Biophys Acta. 1991. PMID: 1756177
Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease.
De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B, Van Leuven F, Van den Berghe H. De Strooper B, et al. J Biol Chem. 1995 Feb 24;270(8):4058-65. doi: 10.1074/jbc.270.8.4058. J Biol Chem. 1995. PMID: 7876155
Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.
De Strooper B, Umans L, Van Leuven F, Van Den Berghe H. De Strooper B, et al. J Cell Biol. 1993 Apr;121(2):295-304. doi: 10.1083/jcb.121.2.295. J Cell Biol. 1993. PMID: 8468348 Free PMC article.
We have previously shown that APP-secretase activity is not inhibited by exogenously added proteinase inhibitors of different specificity (De Strooper, B., F. ...
We have previously shown that APP-secretase activity is not inhibited by exogenously added proteinase inhibitors of different specificity ( …
Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.
Moechars D, Lorent K, De Strooper B, Dewachter I, Van Leuven F. Moechars D, et al. EMBO J. 1996 Mar 15;15(6):1265-74. EMBO J. 1996. PMID: 8635459 Free PMC article.
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. De Strooper B, et al. Nature. 1998 Jan 22;391(6665):387-90. doi: 10.1038/34910. Nature. 1998. PMID: 9450754
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