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Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.
Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L. Szaruga M, et al. Among authors: de strooper b, de vos t. Cell. 2017 Jul 27;170(3):443-456.e14. doi: 10.1016/j.cell.2017.07.004. Cell. 2017. PMID: 28753424 Free article.
Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.
De Strooper B, Umans L, Van Leuven F, Van Den Berghe H. De Strooper B, et al. J Cell Biol. 1993 Apr;121(2):295-304. doi: 10.1083/jcb.121.2.295. J Cell Biol. 1993. PMID: 8468348 Free PMC article.
We have previously shown that APP-secretase activity is not inhibited by exogenously added proteinase inhibitors of different specificity (De Strooper, B., F. Van Leuven, and H. Van Den Berghe. 1992. FEBS (Fed. ...
We have previously shown that APP-secretase activity is not inhibited by exogenously added proteinase inhibitors of different specificity ( …
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.
Kumar-Singh S, De Jonghe C, Cruts M, Kleinert R, Wang R, Mercken M, De Strooper B, Vanderstichele H, Löfgren A, Vanderhoeven I, Backhovens H, Vanmechelen E, Kroisel PM, Van Broeckhoven C. Kumar-Singh S, et al. Among authors: de jonghe c, de strooper b. Hum Mol Genet. 2000 Nov 1;9(18):2589-98. doi: 10.1093/hmg/9.18.2589. Hum Mol Genet. 2000. PMID: 11063718
A cell biological perspective on Alzheimer's disease.
Annaert W, De Strooper B. Annaert W, et al. Among authors: de strooper b. Annu Rev Cell Dev Biol. 2002;18:25-51. doi: 10.1146/annurev.cellbio.18.020402.142302. Epub 2002 Apr 2. Annu Rev Cell Dev Biol. 2002. PMID: 12142279 Review.
394 results