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AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo.
Faubert B, Boily G, Izreig S, Griss T, Samborska B, Dong Z, Dupuy F, Chambers C, Fuerth BJ, Viollet B, Mamer OA, Avizonis D, DeBerardinis RJ, Siegel PM, Jones RG. Faubert B, et al. Among authors: deberardinis rj. Cell Metab. 2013 Jan 8;17(1):113-24. doi: 10.1016/j.cmet.2012.12.001. Epub 2012 Dec 27. Cell Metab. 2013. PMID: 23274086 Free PMC article.
Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels.
Srivastava N, Kollipara RK, Singh DK, Sudderth J, Hu Z, Nguyen H, Wang S, Humphries CG, Carstens R, Huffman KE, DeBerardinis RJ, Kittler R. Srivastava N, et al. Among authors: deberardinis rj. Cell Metab. 2014 Oct 7;20(4):650-61. doi: 10.1016/j.cmet.2014.08.003. Epub 2014 Sep 25. Cell Metab. 2014. PMID: 25264247 Free PMC article.
Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction.
Cetinbas N, Daugaard M, Mullen AR, Hajee S, Rotblat B, Lopez A, Li A, DeBerardinis RJ, Sorensen PH. Cetinbas N, et al. Among authors: deberardinis rj. Oncogene. 2015 Jul 23;34(30):4005-10. doi: 10.1038/onc.2014.316. Epub 2014 Oct 6. Oncogene. 2015. PMID: 25284589 Free PMC article.
Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.
Jin L, Li D, Alesi GN, Fan J, Kang HB, Lu Z, Boggon TJ, Jin P, Yi H, Wright ER, Duong D, Seyfried NT, Egnatchik R, DeBerardinis RJ, Magliocca KR, He C, Arellano ML, Khoury HJ, Shin DM, Khuri FR, Kang S. Jin L, et al. Among authors: deberardinis rj. Cancer Cell. 2015 Feb 9;27(2):257-70. doi: 10.1016/j.ccell.2014.12.006. Cancer Cell. 2015. PMID: 25670081 Free PMC article.
281 results