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Benign prostatic hyperplasia nodules in patients treated with celecoxib and/or finasteride have reduced levels of NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, a mitochondrial protein essential for efficient function of the electron transport chain.
Liu TT, Igarashi T, El-Khoury N, Ihejirika N, Paxton K, Jaumotte J, Dhir R, Hudson CN, Nelson JB, DeFranco DB, Yoshimura N, Wang Z, Pascal LE. Liu TT, et al. Among authors: defranco db. Prostate. 2024 Oct;84(14):1309-1319. doi: 10.1002/pros.24766. Epub 2024 Jul 14. Prostate. 2024. PMID: 39004950 Free PMC article.
Mitochondrial dysfunction in urologic disease.
Adrian AE, Boucher NJ, McVary KT, DeFranco DB, Ricke WA. Adrian AE, et al. Among authors: defranco db. Prostate Cancer Prostatic Dis. 2026 Mar 24. doi: 10.1038/s41391-026-01097-5. Online ahead of print. Prostate Cancer Prostatic Dis. 2026. PMID: 41876711 Review.
The SARS-CoV-2 E protein induces Toll-like receptor 2-mediated neonatal lung injury in a model of COVID-19 viremia that is rescued by the glucocorticoid ciclesonide.
Menden HL, Mabry SM, Venkatraman A, Xia S, DeFranco DB, Yu W, Sampath V. Menden HL, et al. Among authors: defranco db. Am J Physiol Lung Cell Mol Physiol. 2023 May 1;324(5):L722-L736. doi: 10.1152/ajplung.00410.2022. Epub 2023 Mar 28. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 36976925 Free PMC article.
ZC3H4, a novel regulator of mitochondrial complex I, impacts prostate stromal cell senescence, attachment, adhesion and anoikis resistance.
Liu TT, Carrarini MJ, Myklebust LK, Skalitzky KO, El-Khoury N, Sipula IJ, Chang A, Soman V, Liu A, Ihejirika N, Chandran UR, Jurczak MJ, Ricke WA, DeFranco DB, Pascal LE. Liu TT, et al. Among authors: defranco db. Cell Death Dis. 2025 Oct 21;16(1):741. doi: 10.1038/s41419-025-08027-8. Cell Death Dis. 2025. PMID: 41120279 Free PMC article.
Physiologic and structural characterization of desisobutyryl-ciclesonide, a selective glucocorticoid receptor modulator in newborn rats.
Jaumotte JD, El Khoury N, Min CK, Wang J, Madigan C, Jano A, Russo Kobylski RJ, Solt LA, Dhavan RS, Short KL, Lei T, Chandran U, Cole TJ, Monaghan-Nichols AP, Sampath V, Houtman R, Nettles KW, DeFranco DB. Jaumotte JD, et al. Among authors: defranco db. PNAS Nexus. 2024 Dec 26;4(1):pgae573. doi: 10.1093/pnasnexus/pgae573. eCollection 2025 Jan. PNAS Nexus. 2024. PMID: 39781096 Free PMC article.
Residency Program Directors' Views on Research Conducted During Medical School: A National Survey.
Wolfson RK, Fairchild PC, Bahner I, Baxa DM, Birnbaum DR, Chaudhry SI, Chretien KC, DeFranco DB, Deptola AZ, LaConte LEW, Lin JJ, Petch Lee L, Powers MA, Ropson IJ, Sankaran SM, Sawarynski KE, Sozio SM. Wolfson RK, et al. Among authors: defranco db. Acad Med. 2023 Oct 1;98(10):1185-1195. doi: 10.1097/ACM.0000000000005256. Epub 2023 Apr 21. Acad Med. 2023. PMID: 37099328 Free PMC article.
166 results