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Drug transporters in drug efficacy and toxicity.
DeGorter MK, Xia CQ, Yang JJ, Kim RB. DeGorter MK, et al. Annu Rev Pharmacol Toxicol. 2012;52:249-73. doi: 10.1146/annurev-pharmtox-010611-134529. Epub 2011 Sep 19. Annu Rev Pharmacol Toxicol. 2012. PMID: 21942630 Review.
Efficacy and plasma drug concentrations with nondaily dosing of rosuvastatin.
Goldberg AS, DeGorter MK, Ban MR, Kim RB, Hegele RA. Goldberg AS, et al. Among authors: degorter mk. Can J Cardiol. 2013 Aug;29(8):915-9. doi: 10.1016/j.cjca.2012.12.015. Epub 2013 Mar 5. Can J Cardiol. 2013. PMID: 23465343
Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity.
DeGorter MK, Ho RH, Leake BF, Tirona RG, Kim RB. DeGorter MK, et al. Mol Pharm. 2012 Apr 2;9(4):986-95. doi: 10.1021/mp200629s. Epub 2012 Mar 6. Mol Pharm. 2012. PMID: 22352740 Free PMC article.
Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentrations in routine clinical care.
DeGorter MK, Tirona RG, Schwarz UI, Choi YH, Dresser GK, Suskin N, Myers K, Zou G, Iwuchukwu O, Wei WQ, Wilke RA, Hegele RA, Kim RB. DeGorter MK, et al. Circ Cardiovasc Genet. 2013 Aug;6(4):400-8. doi: 10.1161/CIRCGENETICS.113.000099. Epub 2013 Jul 22. Circ Cardiovasc Genet. 2013. PMID: 23876492 Free PMC article. Clinical Trial.
Disposition of atorvastatin, rosuvastatin, and simvastatin in oatp1b2-/- mice and intraindividual variability in human subjects.
DeGorter MK, Urquhart BL, Gradhand U, Tirona RG, Kim RB. DeGorter MK, et al. J Clin Pharmacol. 2012 Nov;52(11):1689-97. doi: 10.1177/0091270011422815. Epub 2011 Dec 13. J Clin Pharmacol. 2012. PMID: 22167570 Clinical Trial.
Use of transgenic and knockout mouse models to assess solute carrier transporter function.
DeGorter MK, Kim RB. DeGorter MK, et al. Clin Pharmacol Ther. 2011 Apr;89(4):612-6. doi: 10.1038/clpt.2011.2. Epub 2011 Feb 23. Clin Pharmacol Ther. 2011. PMID: 21346748 No abstract available.
Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease.
Wilson A, Teft WA, Morse BL, Choi YH, Woolsey S, DeGorter MK, Hegele RA, Tirona RG, Kim RB. Wilson A, et al. Among authors: degorter mk. Dig Dis Sci. 2015 Dec;60(12):3620-30. doi: 10.1007/s10620-015-3797-3. Epub 2015 Jul 10. Dig Dis Sci. 2015. PMID: 26160437
Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response.
Gong IY, Crown N, Suen CM, Schwarz UI, Dresser GK, Knauer MJ, Sugiyama D, DeGorter MK, Woolsey S, Tirona RG, Kim RB. Gong IY, et al. Among authors: degorter mk. Eur Heart J. 2012 Nov;33(22):2856-2464a. doi: 10.1093/eurheartj/ehs042. Epub 2012 Feb 27. Eur Heart J. 2012. PMID: 22374717
Incremental lowering of low-density lipoprotein cholesterol with ezetimibe 20 mg vs 10 mg daily in patients receiving concomitant statin therapy.
Ziada A, Schwarz UI, DeGorter MK, Tirona RG, Ban MR, Kim RB, Hegele RA. Ziada A, et al. Among authors: degorter mk. Can J Cardiol. 2013 Nov;29(11):1395-9. doi: 10.1016/j.cjca.2013.08.003. Can J Cardiol. 2013. PMID: 24182755
Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3).
Grant CE, Gao M, DeGorter MK, Cole SP, Deeley RG. Grant CE, et al. Among authors: degorter mk. Drug Metab Dispos. 2008 Dec;36(12):2571-81. doi: 10.1124/dmd.108.022491. Epub 2008 Sep 5. Drug Metab Dispos. 2008. PMID: 18775981
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