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404 results
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LKB1 (XEEK1) regulates Wnt signalling in vertebrate development.
Ossipova O, Bardeesy N, DePinho RA, Green JB. Ossipova O, et al. Among authors: depinho ra. Nat Cell Biol. 2003 Oct;5(10):889-94. doi: 10.1038/ncb1048. Epub 2003 Sep 14. Nat Cell Biol. 2003. PMID: 12973359
The INK4a/ARF tumor suppressor: one gene--two products--two pathways.
Chin L, Pomerantz J, DePinho RA. Chin L, et al. Among authors: depinho ra. Trends Biochem Sci. 1998 Aug;23(8):291-6. doi: 10.1016/s0968-0004(98)01236-5. Trends Biochem Sci. 1998. PMID: 9757829 Review.
Longevity, stress response, and cancer in aging telomerase-deficient mice.
Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, DePinho RA. Rudolph KL, et al. Among authors: depinho ra. Cell. 1999 Mar 5;96(5):701-12. doi: 10.1016/s0092-8674(00)80580-2. Cell. 1999. PMID: 10089885
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis.
Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, Greider CW, DePinho RA. Chin L, et al. Among authors: depinho ra. Cell. 1999 May 14;97(4):527-38. doi: 10.1016/s0092-8674(00)80762-x. Cell. 1999. PMID: 10338216
Essential role for oncogenic Ras in tumour maintenance.
Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, Horner JW 2nd, Cordon-Cardo C, Yancopoulos GD, DePinho RA. Chin L, et al. Among authors: depinho ra. Nature. 1999 Jul 29;400(6743):468-72. doi: 10.1038/22788. Nature. 1999. PMID: 10440378
Gene-target recognition among members of the myc superfamily and implications for oncogenesis.
O'Hagan RC, Schreiber-Agus N, Chen K, David G, Engelman JA, Schwab R, Alland L, Thomson C, Ronning DR, Sacchettini JC, Meltzer P, DePinho RA. O'Hagan RC, et al. Among authors: depinho ra. Nat Genet. 2000 Feb;24(2):113-9. doi: 10.1038/72761. Nat Genet. 2000. PMID: 10655054
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.
Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA, Alt FW. Gao Y, et al. Among authors: depinho ra. Nature. 2000 Apr 20;404(6780):897-900. doi: 10.1038/35009138. Nature. 2000. PMID: 10786799
Mice without telomerase: what can they teach us about human cancer?
Artandi SE, DePinho RA. Artandi SE, et al. Among authors: depinho ra. Nat Med. 2000 Aug;6(8):852-5. doi: 10.1038/78595. Nat Med. 2000. PMID: 10932211 Review.
Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or promotion of cancer....
Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instabi …
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice.
Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L, DePinho RA. Artandi SE, et al. Among authors: depinho ra. Nature. 2000 Aug 10;406(6796):641-5. doi: 10.1038/35020592. Nature. 2000. PMID: 10949306
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