Dean RA - Search Results

1

Quantitative analysis of amyloid beta peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry.

Oe T, Ackermann BL, Inoue K, Berna MJ, Garner CO, Gelfanova V, Dean RA, Siemers ER, Holtzman DM, Farlow MR, Blair IA. Oe T, et al. Among authors: dean ra. Rapid Commun Mass Spectrom. 2006;20(24):3723-35. doi: 10.1002/rcm.2787. Rapid Commun Mass Spectrom. 2006. PMID: 17117458

2

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers.

Siemers E, Skinner M, Dean RA, Gonzales C, Satterwhite J, Farlow M, Ness D, May PC. Siemers E, et al. Among authors: dean ra. Clin Neuropharmacol. 2005 May-Jun;28(3):126-32. doi: 10.1097/01.wnf.0000167360.27670.29. Clin Neuropharmacol. 2005. PMID: 15965311 Clinical Trial.

3

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.

Siemers ER, Quinn JF, Kaye J, Farlow MR, Porsteinsson A, Tariot P, Zoulnouni P, Galvin JE, Holtzman DM, Knopman DS, Satterwhite J, Gonzales C, Dean RA, May PC. Siemers ER, et al. Among authors: dean ra. Neurology. 2006 Feb 28;66(4):602-4. doi: 10.1212/01.WNL.0000198762.41312.E1. Neurology. 2006. PMID: 16505324 Clinical Trial.

4

New pathways in drug discovery for Alzheimer's disease.

Siemers ER, Dean RA, Demattos R, May PC. Siemers ER, et al. Among authors: dean ra. Curr Neurol Neurosci Rep. 2006 Sep;6(5):372-8. doi: 10.1007/s11910-996-0017-8. Curr Neurol Neurosci Rep. 2006. PMID: 16928346 Review.

5

Identifying pharmacodynamic protein markers of centrally active drugs in humans: a pilot study in a novel clinical model.

Patil ST, Higgs RE, Brandt JE, Knierman MD, Gelfanova V, Butler JP, Downing AM, Dorocke J, Dean RA, Potter WZ, Michelson D, Pan AX, Jhee SS, Hale JE. Patil ST, et al. Among authors: dean ra. J Proteome Res. 2007 Mar;6(3):955-66. doi: 10.1021/pr0603710. Epub 2007 Jan 23. J Proteome Res. 2007. PMID: 17243662

6

Quantitative analysis of amyloid-beta peptides in cerebrospinal fluid using immunoprecipitation and MALDI-Tof mass spectrometry.

Gelfanova V, Higgs RE, Dean RA, Holtzman DM, Farlow MR, Siemers ER, Boodhoo A, Qian YW, He X, Jin Z, Fisher DL, Cox KL, Hale JE. Gelfanova V, et al. Among authors: dean ra. Brief Funct Genomic Proteomic. 2007 Jun;6(2):149-58. doi: 10.1093/bfgp/elm010. Epub 2007 Jun 20. Brief Funct Genomic Proteomic. 2007. PMID: 17584762

7

Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase.

Siemers ER, Dean RA, Friedrich S, Ferguson-Sells L, Gonzales C, Farlow MR, May PC. Siemers ER, et al. Among authors: dean ra. Clin Neuropharmacol. 2007 Nov-Dec;30(6):317-25. doi: 10.1097/WNF.0b013e31805b7660. Clin Neuropharmacol. 2007. PMID: 18090456 Clinical Trial.

8

Proteomics of cerebrospinal fluid: methods for sample processing.

Hale JE, Gelfanova V, You JS, Knierman MD, Dean RA. Hale JE, et al. Among authors: dean ra. Methods Mol Biol. 2008;425:53-66. doi: 10.1007/978-1-60327-210-0_5. Methods Mol Biol. 2008. PMID: 18369886

9

Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease.

Fleisher AS, Raman R, Siemers ER, Becerra L, Clark CM, Dean RA, Farlow MR, Galvin JE, Peskind ER, Quinn JF, Sherzai A, Sowell BB, Aisen PS, Thal LJ. Fleisher AS, et al. Among authors: dean ra. Arch Neurol. 2008 Aug;65(8):1031-8. doi: 10.1001/archneur.65.8.1031. Arch Neurol. 2008. PMID: 18695053 Free PMC article. Clinical Trial.

10

The influence of matrix type, diurnal rhythm and sample collection and processing on the measurement of plasma beta-amyloid isoforms using the INNO-BIA plasma Abeta forms multiplex assay.

Lachno DR, Vanderstichele H, De Groote G, Kostanjevecki V, De Meyer G, Siemers ER, Willey MB, Bourdage JS, Konrad RJ, Dean RA. Lachno DR, et al. Among authors: dean ra. J Nutr Health Aging. 2009 Mar;13(3):220-5. doi: 10.1007/s12603-009-0062-5. J Nutr Health Aging. 2009. PMID: 19262957 Free article.

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