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Death domain-associated protein 6 (Daxx) selectively represses IL-6 transcription through histone deacetylase 1 (HDAC1)-mediated histone deacetylation in macrophages.
Yao Z, Zhang Q, Li X, Zhao D, Liu Y, Zhao K, Liu Y, Wang C, Jiang M, Li N, Cao X. Yao Z, et al. J Biol Chem. 2014 Mar 28;289(13):9372-9. doi: 10.1074/jbc.M113.533992. Epub 2014 Feb 18. J Biol Chem. 2014. PMID: 24550390 Free PMC article.
Further mechanism analyses show that histone deacetylase 1 (HDAC1) interacts with Daxx and binds to the promoter of IL-6. Daxx silencing decreases the association of HDAC1 to IL-6 promoter. Therefore, ou …
Further mechanism analyses show that histone deacetylase 1 (HDAC1) interacts with Daxx and binds to the p …