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Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes.
Hanley PJ, Cruz CR, Savoldo B, Leen AM, Stanojevic M, Khalil M, Decker W, Molldrem JJ, Liu H, Gee AP, Rooney CM, Heslop HE, Dotti G, Brenner MK, Shpall EJ, Bollard CM. Hanley PJ, et al. Blood. 2009 Aug 27;114(9):1958-67. doi: 10.1182/blood-2009-03-213256. Epub 2009 May 14. Blood. 2009. PMID: 19443656 Free PMC article.
CD3(+) and/or CD14(+) depletion from cord blood mononuclear cells before ex vivo expansion culture improves total nucleated cell and CD34(+) cell yields.
Yang H, Robinson SN, Lu J, Decker WK, Xing D, Steiner D, Parmar S, Shah N, Champlin RE, Munsell M, Leen A, Bollard C, Simmons PJ, Shpall EJ. Yang H, et al. Among authors: decker wk. Bone Marrow Transplant. 2010 Jun;45(6):1000-7. doi: 10.1038/bmt.2009.289. Epub 2009 Oct 19. Bone Marrow Transplant. 2010. PMID: 19838220 Free PMC article.
AML-loaded DC generate Th1-type cellular immune responses in vitro.
Xing D, Decker WK, Li S, Robinson SN, Yang H, Segal H, O'Connor S, Yao X, Komanduri KV, McMannis JD, Jones RB, de Lima M, Champlin RE, Shpall EJ. Xing D, et al. Among authors: decker wk. Cytotherapy. 2006;8(2):95-104. doi: 10.1080/14653240600620093. Cytotherapy. 2006. PMID: 16698683
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