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LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase.
Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KLB, Rauscher FJ 3rd. Peng H, et al. Among authors: dedhar s. Cancer Res. 2014 Mar 1;74(5):1390-1403. doi: 10.1158/0008-5472.CAN-13-1275. Cancer Res. 2014. PMID: 24590809 Free PMC article.
Integrins and signal transduction.
Dedhar S. Dedhar S. Curr Opin Hematol. 1999 Jan;6(1):37-43. doi: 10.1097/00062752-199901000-00007. Curr Opin Hematol. 1999. PMID: 9915552 Review.
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