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Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities.
Harmon DB, Mandler WK, Sipula IJ, Dedousis N, Lewis SE, Eckels JT, Du J, Wang Y, Huckestein BR, Pagano PJ, Cifuentes-Pagano E, Homanics GE, Van't Erve TJ, Stefanovic-Racic M, Jurczak MJ, O'Doherty RM, Kelley EE. Harmon DB, et al. Among authors: dedousis n. Diabetes. 2019 Jun;68(6):1221-1229. doi: 10.2337/db18-1198. Epub 2019 Apr 1. Diabetes. 2019. PMID: 30936145 Free PMC article.
Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver.
Stefanovic-Racic M, Yang X, Turner MS, Mantell BS, Stolz DB, Sumpter TL, Sipula IJ, Dedousis N, Scott DK, Morel PA, Thomson AW, O'Doherty RM. Stefanovic-Racic M, et al. Among authors: dedousis n. Diabetes. 2012 Sep;61(9):2330-9. doi: 10.2337/db11-1523. Epub 2012 Jul 30. Diabetes. 2012. PMID: 22851575 Free PMC article.
Kupffer cells facilitate the acute effects of leptin on hepatic lipid metabolism.
Metlakunta A, Huang W, Stefanovic-Racic M, Dedousis N, Sipula I, O'Doherty RM. Metlakunta A, et al. Among authors: dedousis n. Am J Physiol Endocrinol Metab. 2017 Jan 1;312(1):E11-E18. doi: 10.1152/ajpendo.00250.2016. Epub 2016 Nov 8. Am J Physiol Endocrinol Metab. 2017. PMID: 27827807 Free PMC article.
DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet.
Zhang P, Chu T, Dedousis N, Mantell BS, Sipula I, Li L, Bunce KD, Shaw PA, Katz LS, Zhu J, Argmann C, O'Doherty RM, Peters DG, Scott DK. Zhang P, et al. Among authors: dedousis n. Mol Metab. 2017 Feb 3;6(4):327-339. doi: 10.1016/j.molmet.2017.02.001. eCollection 2017 Apr. Mol Metab. 2017. PMID: 28377872 Free PMC article.
Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply.
Harmon DB, Wu C, Dedousis N, Sipula IJ, Stefanovic-Racic M, Schoiswohl G, O'Donnell CP, Alonso LC, Kershaw EE, Kelley EE, O'Doherty RM. Harmon DB, et al. Among authors: dedousis n. Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E758-E770. doi: 10.1152/ajpendo.00172.2018. Epub 2018 Aug 7. Am J Physiol Endocrinol Metab. 2018. PMID: 30086648 Free PMC article.
25 results