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18 results
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Epigenetic regulation of genomic integrity.
Deem AK, Li X, Tyler JK. Deem AK, et al. Chromosoma. 2012 Apr;121(2):131-51. doi: 10.1007/s00412-011-0358-1. Epub 2012 Jan 17. Chromosoma. 2012. PMID: 22249206 Free PMC article. Review.
Delineation of the role of chromatin assembly and the Rtt101Mms1 E3 ubiquitin ligase in DNA damage checkpoint recovery in budding yeast.
Diao LT, Chen CC, Dennehey B, Pal S, Wang P, Shen ZJ, Deem A, Tyler JK. Diao LT, et al. PLoS One. 2017 Jul 27;12(7):e0180556. doi: 10.1371/journal.pone.0180556. eCollection 2017. PLoS One. 2017. PMID: 28749957 Free PMC article.
Migrating bubble during break-induced replication drives conservative DNA synthesis.
Saini N, Ramakrishnan S, Elango R, Ayyar S, Zhang Y, Deem A, Ira G, Haber JE, Lobachev KS, Malkova A. Saini N, et al. Nature. 2013 Oct 17;502(7471):389-92. doi: 10.1038/nature12584. Epub 2013 Sep 11. Nature. 2013. PMID: 24025772 Free PMC article.
Microhomology directs diverse DNA break repair pathways and chromosomal translocations.
Villarreal DD, Lee K, Deem A, Shim EY, Malkova A, Lee SE. Villarreal DD, et al. PLoS Genet. 2012;8(11):e1003026. doi: 10.1371/journal.pgen.1003026. Epub 2012 Nov 8. PLoS Genet. 2012. PMID: 23144625 Free PMC article.
Large inverted repeats in the vicinity of a single double-strand break strongly affect repair in yeast diploids lacking Rad51.
Downing B, Morgan R, VanHulle K, Deem A, Malkova A. Downing B, et al. Mutat Res. 2008 Oct 14;645(1-2):9-18. doi: 10.1016/j.mrfmmm.2008.07.013. Epub 2008 Aug 5. Mutat Res. 2008. PMID: 18755201 Free PMC article.
Translesion Polymerases Drive Microhomology-Mediated Break-Induced Replication Leading to Complex Chromosomal Rearrangements.
Sakofsky CJ, Ayyar S, Deem AK, Chung WH, Ira G, Malkova A. Sakofsky CJ, et al. Among authors: deem ak. Mol Cell. 2015 Dec 17;60(6):860-72. doi: 10.1016/j.molcel.2015.10.041. Epub 2015 Dec 6. Mol Cell. 2015. PMID: 26669261 Free PMC article.
Defective break-induced replication leads to half-crossovers in Saccharomyces cerevisiae.
Deem A, Barker K, Vanhulle K, Downing B, Vayl A, Malkova A. Deem A, et al. Genetics. 2008 Aug;179(4):1845-60. doi: 10.1534/genetics.108.087940. Epub 2008 Aug 9. Genetics. 2008. PMID: 18689895 Free PMC article.
Break-induced replication is highly inaccurate.
Deem A, Keszthelyi A, Blackgrove T, Vayl A, Coffey B, Mathur R, Chabes A, Malkova A. Deem A, et al. PLoS Biol. 2011 Feb 15;9(2):e1000594. doi: 10.1371/journal.pbio.1000594. PLoS Biol. 2011. PMID: 21347245 Free PMC article.
An inhibitor of oxidative phosphorylation exploits cancer vulnerability.
Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip AA, Al-Atrash G, Asara J, Bardenhagen J, Carrillo CC, Carroll C, Chang E, Ciurea S, Cross JB, Czako B, Deem A, Daver N, de Groot JF, Dong JW, Feng N, Gao G, Gay J, Do MG, Greer J, Giuliani V, Han J, Han L, Henry VK, Hirst J, Huang S, Jiang Y, Kang Z, Khor T, Konoplev S, Lin YH, Liu G, Lodi A, Lofton T, Ma H, Mahendra M, Matre P, Mullinax R, Peoples M, Petrocchi A, Rodriguez-Canale J, Serreli R, Shi T, Smith M, Tabe Y, Theroff J, Tiziani S, Xu Q, Zhang Q, Muller F, DePinho RA, Toniatti C, Draetta GF, Heffernan TP, Konopleva M, Jones P, Di Francesco ME, Marszalek JR. Molina JR, et al. Nat Med. 2018 Jul;24(7):1036-1046. doi: 10.1038/s41591-018-0052-4. Epub 2018 Jun 11. Nat Med. 2018. PMID: 29892070
Cascades of genetic instability resulting from compromised break-induced replication.
Vasan S, Deem A, Ramakrishnan S, Argueso JL, Malkova A. Vasan S, et al. PLoS Genet. 2014 Feb 27;10(2):e1004119. doi: 10.1371/journal.pgen.1004119. eCollection 2014 Feb. PLoS Genet. 2014. PMID: 24586181 Free PMC article.
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