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562 results

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Page 1
Intramolecular inhibition of human defensin HNP-1 by its propiece.
Valore EV, Martin E, Harwig SS, Ganz T. Valore EV, et al. J Clin Invest. 1996 Apr 1;97(7):1624-9. doi: 10.1172/JCI118588. J Clin Invest. 1996. PMID: 8601627 Free PMC article.
We examined mechanisms that protect host defense cells from their cytotoxic effector molecules. Human neutrophil peptides (HNP) 1-3 are microbicidal and cytotoxic defensins, initially synthesized as 94-amino acid preproHNP(1-94), cotranslationally proteolyzed …
We examined mechanisms that protect host defense cells from their cytotoxic effector molecules. Human neutrophil peptides (HNP) 1 …
HNP-1: From Structure to Application Thanks to Multifaceted Functions.
Zhang J, Liu Z, Zhou Z, Huang Z, Yang Y, Wu J, Liu Y. Zhang J, et al. Microorganisms. 2025 Feb 19;13(2):458. doi: 10.3390/microorganisms13020458. Microorganisms. 2025. PMID: 40005828 Free PMC article. Review.
Antimicrobial peptides (AMPs) are critical components of innate immunity in animals and plants, exhibiting thrilling prospectives as alternatives to traditional antibiotics due to their ability to combat pathogens without leading to resistance. Among these, Human Neutro …
Antimicrobial peptides (AMPs) are critical components of innate immunity in animals and plants, exhibiting thrilling prospectives as alterna …
Determination of defensin HNP-1, HNP-2, and HNP-3 in human saliva by using LC/MS.
Goebel C, Mackay LG, Vickers ER, Mather LE. Goebel C, et al. Peptides. 2000 Jun;21(6):757-65. doi: 10.1016/s0196-9781(00)00205-9. Peptides. 2000. PMID: 10958994
The aim is to develop a profile that could be useful for the assessment of patients and their treatment programs, as well as identifying unknown compounds observed in saliva. Defensin human neutrophil peptide-1 (HNP-1) and defen …
The aim is to develop a profile that could be useful for the assessment of patients and their treatment programs, as well as identifying unk …
Defensins.
Ganz T, Selsted ME, Lehrer RI. Ganz T, et al. Eur J Haematol. 1990 Jan;44(1):1-8. doi: 10.1111/j.1600-0609.1990.tb00339.x. Eur J Haematol. 1990. PMID: 2407547 Review.
Three defensins, HNP-1, 2, and 3, comprise 30-50% of total protein in azurophil granules of human neutrophils. ...The three-dimensional fold of defensins forms a highly amphiphilic molecule. Microbicidal and cytotoxic properties of defensins are …
Three defensins, HNP-1, 2, and 3, comprise 30-50% of total protein in azurophil granules of human neutrophils. ...The t …
Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines.
Varkey J, Nagaraj R. Varkey J, et al. Antimicrob Agents Chemother. 2005 Nov;49(11):4561-6. doi: 10.1128/AAC.49.11.4561-4566.2005. Antimicrob Agents Chemother. 2005. PMID: 16251296 Free PMC article.
The antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines has been investigated. A peptide corresponding to the HNP-1 sequence without the six cysteines (HNP-1deltaC) exhibited antibacterial activity toward gram-neg …
The antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines has been investigated. A peptid …
Determination of defensin HNP-1 in human saliva of patients with oral mucosal diseases.
Küçükkolbaşi H, Küçükkolbaşi S, Dursun R, Ayyildiz F, Kara H. Küçükkolbaşi H, et al. J Immunoassay Immunochem. 2011;32(4):284-95. doi: 10.1080/15321819.2011.569045. J Immunoassay Immunochem. 2011. PMID: 21728821
Defensin human neutrophil peptide-1 (HNP-1) was identified and confirmed. The concentration of HNP-1 in saliva was determined by comparing the area of eluted HNP-1 with that of HNP-1 standa …
Defensin human neutrophil peptide-1 (HNP-1) was identified and confirmed. The concentration …
Newly Identified HNP-F from Human Neutrophil Peptide-1 Promotes Hemostasis.
Kim KC, Lee W, Lee J, Cha HJ, Hwang BH. Kim KC, et al. Biotechnol J. 2019 Jul;14(7):e1800606. doi: 10.1002/biot.201800606. Epub 2019 May 2. Biotechnol J. 2019. PMID: 30927490
Active hemostats have several advantages including utilization of natural blood coagulation and biocompatibility. Among them, although human neutrophil peptide-1 (HNP-1) has been previously reported with the hemostatic mechanism, which pa …
Active hemostats have several advantages including utilization of natural blood coagulation and biocompatibility. Among them, although hu …
Computational evaluation of modified peptides from human neutrophil peptide 1 (HNP-1).
Moazzezy N, Rismani E, Rezaei M, Karam MRA, Rafati S, Bouzari S, Oloomi M. Moazzezy N, et al. J Biomol Struct Dyn. 2022 Feb;40(3):1163-1171. doi: 10.1080/07391102.2020.1823249. Epub 2020 Sep 26. J Biomol Struct Dyn. 2022. PMID: 32981420
One of the most accessible targets for alpha-defensins human neutrophil peptide-1 (HNP-1) is lipid II. In the present study, we performed homology modeling and geometrical validation of human neutrophil defensin 1. ...Molecu …
One of the most accessible targets for alpha-defensins human neutrophil peptide-1 (HNP-1) i …
Recombinant HNP-1 Produced by Escherichia coli Triggers Bacterial Apoptosis and Exhibits Antibacterial Activity against Drug-Resistant Bacteria.
Xie Q, Wang Y, Zhang M, Wu S, Wei W, Xiao W, Wang Y, Zhao J, Liu N, Jin Y, Wu J, Xu P. Xie Q, et al. Microbiol Spectr. 2022 Feb 23;10(1):e0086021. doi: 10.1128/spectrum.00860-21. Epub 2022 Jan 12. Microbiol Spectr. 2022. PMID: 35019682 Free PMC article.
Human neutrophil peptide-1 (HNP-1) is a promising antibiotic candidate, but its clinical applications have been hampered by challenges during mass production and an inadequate understanding of its bactericidal mechanisms. ...IMPORTANCE …
Human neutrophil peptide-1 (HNP-1) is a promising antibiotic candidate, but its clinical applicati …
Diagnostic and Therapeutic Potential for HNP-1, HBD-1 and HBD-4 in Pregnant Women with COVID-19.
Brancaccio M, Mennitti C, Calvanese M, Gentile A, Musto R, Gaudiello G, Scamardella G, Terracciano D, Frisso G, Pero R, Sarno L, Guida M, Scudiero O. Brancaccio M, et al. Int J Mol Sci. 2022 Mar 22;23(7):3450. doi: 10.3390/ijms23073450. Int J Mol Sci. 2022. PMID: 35408809 Free PMC article.
Following that, this study aims to compare the levels of various cytokines and to investigate the role of defensins between pregnant women with confirmed COVID-19 infection and pregnant women without any defined risk factor. TNF-alpha, TGF-beta, IL-2 and IL-10, beta-def …
Following that, this study aims to compare the levels of various cytokines and to investigate the role of defensins between pregnant …
562 results