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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1969 1
1970 1
1972 2
1973 1
1974 3
1975 2
1977 1
1979 1
1980 1
1981 2
1982 2
1983 4
1984 2
1985 2
1986 2
1988 1
1989 1
1990 2
1991 1
1993 3
1994 4
1996 3
1998 4
1999 4
2000 7
2001 2
2002 5
2003 9
2004 11
2005 7
2006 6
2007 7
2008 4
2009 4
2010 3
2011 10
2012 7
2013 2
2014 3
2015 4
2016 4
2017 2
2018 3
2019 4
2020 3
2021 3
2022 1
2023 1
2024 0

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156 results

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Page 1
Copper deficiency anemia: review article.
Myint ZW, Oo TH, Thein KZ, Tun AM, Saeed H. Myint ZW, et al. Ann Hematol. 2018 Sep;97(9):1527-1534. doi: 10.1007/s00277-018-3407-5. Epub 2018 Jun 29. Ann Hematol. 2018. PMID: 29959467 Review.
Although zinc absorption may occur by direct interaction with the Ctr1 transporter, its absorption is slightly different. Copper deficiency affects physiologic systems such as bone marrow hematopoiesis, optic nerve function, and the nervous system in general. Detailed path …
Although zinc absorption may occur by direct interaction with the Ctr1 transporter, its absorption is slightly different. Copper deficien
Wilson's disease: overview.
Lucena-Valera A, Ruz-Zafra P, Ampuero J. Lucena-Valera A, et al. Med Clin (Barc). 2023 Mar 24;160(6):261-267. doi: 10.1016/j.medcli.2022.12.016. Epub 2023 Jan 23. Med Clin (Barc). 2023. PMID: 36697289 Review. English, Spanish.
Wilson's disease (WD) is an uncommon hereditary disorder caused by a deficiency in the ATP7B transporter. The protein codified by this gene facilitates the incorporation of the copper into ceruloplasmin. ...The diagnosis requires a combination of clinical signs and …
Wilson's disease (WD) is an uncommon hereditary disorder caused by a deficiency in the ATP7B transporter. The protein codified by thi …
Intersection of Iron and Copper Metabolism in the Mammalian Intestine and Liver.
Doguer C, Ha JH, Collins JF. Doguer C, et al. Compr Physiol. 2018 Sep 14;8(4):1433-1461. doi: 10.1002/cphy.c170045. Compr Physiol. 2018. PMID: 30215866 Free PMC article. Review.
Copper in enterocytes may positively influence iron transport, and hepatic copper may enhance biosynthesis of a circulating ferroxidase, ceruloplasmin, which potentiates iron release from stores. Moreover, many intestinal genes related to iron absorption are transac …
Copper in enterocytes may positively influence iron transport, and hepatic copper may enhance biosynthesis of a circulating ferroxidase
The molecular mechanisms of copper metabolism and its roles in human diseases.
Chen J, Jiang Y, Shi H, Peng Y, Fan X, Li C. Chen J, et al. Pflugers Arch. 2020 Oct;472(10):1415-1429. doi: 10.1007/s00424-020-02412-2. Epub 2020 Jun 7. Pflugers Arch. 2020. PMID: 32506322 Review.
Then, Cu(+) can be secreted into the bile or the blood via the Atox1/ATP7B/ceruloplasmin route. In the bloodstream, this micronutrient can reach peripheral tissues and is again incorporated by Ctr1. ...Copper metabolism must be tightly controlled in order to achieve homeos …
Then, Cu(+) can be secreted into the bile or the blood via the Atox1/ATP7B/ceruloplasmin route. In the bloodstream, this micronutrien …
Aceruloplasminemia.
Kono S. Kono S. Curr Drug Targets. 2012 Aug;13(9):1190-9. doi: 10.2174/138945012802002320. Curr Drug Targets. 2012. PMID: 22515740 Review.
Ceruloplasmin contains 95% of the copper in human serum and plays an important role in iron efflux from mammalian cells, including brain cells, due to the activity of ferroxidase, which oxidizes ferrous iron following its transfer to the cell surface via the iron tr
Ceruloplasmin contains 95% of the copper in human serum and plays an important role in iron efflux from mammalian cells, including br
Copper and Alzheimer's Disease.
Mathys ZK, White AR. Mathys ZK, et al. Adv Neurobiol. 2017;18:199-216. doi: 10.1007/978-3-319-60189-2_10. Adv Neurobiol. 2017. PMID: 28889269 Review.
Of the latter, major changes in copper (Cu) levels and localisation have been identified in AD brain, with accumulation of Cu in amyloid deposits, together with deficiency of Cu in some brain regions. The amyloid precursor protein (APP) and the amyloid beta (Abeta) peptide …
Of the latter, major changes in copper (Cu) levels and localisation have been identified in AD brain, with accumulation of Cu in amyloid dep …
Aceruloplasminemia: an update.
Kono S. Kono S. Int Rev Neurobiol. 2013;110:125-51. doi: 10.1016/B978-0-12-410502-7.00007-7. Int Rev Neurobiol. 2013. PMID: 24209437 Review.
Aceruloplasminemia is an inherited neurodegenerative disorder involving "neurodegeneration with brain iron accumulation," which is caused by genetic defects in the ceruloplasmin gene. Ceruloplasmin is a multicopper oxidase with ferroxidase activity that oxidi …
Aceruloplasminemia is an inherited neurodegenerative disorder involving "neurodegeneration with brain iron accumulation," which is caused by …
Intestinal iron absorption.
Fuqua BK, Vulpe CD, Anderson GJ. Fuqua BK, et al. J Trace Elem Med Biol. 2012 Jun;26(2-3):115-9. doi: 10.1016/j.jtemb.2012.03.015. Epub 2012 May 8. J Trace Elem Med Biol. 2012. PMID: 22575541 Review.
Enterocyte iron is exported to the blood via ferroportin 1 on the basolateral membrane. This transporter acts in partnership with the ferroxidase hephaestin that oxidizes exported ferrous iron to facilitate its binding to plasma transferrin. ...Disturbances in the regulati …
Enterocyte iron is exported to the blood via ferroportin 1 on the basolateral membrane. This transporter acts in partnership with the fer
Does Ceruloplasmin Defend Against Neurodegenerative Diseases?
Wang B, Wang XP. Wang B, et al. Curr Neuropharmacol. 2019;17(6):539-549. doi: 10.2174/1570159X16666180508113025. Curr Neuropharmacol. 2019. PMID: 29737252 Free PMC article. Review.
Ceruloplasmin (CP) is the major copper transport protein in plasma, mainly produced by the liver. ...The fact that patients with genetic disorder aceruloplasminemia do not suffer from tissue copper deficiency, but rather from disruptions in iron metabolism shows ess
Ceruloplasmin (CP) is the major copper transport protein in plasma, mainly produced by the liver. ...The fact that patients with gene
Wilson's disease: A master of disguise.
Hedera P. Hedera P. Parkinsonism Relat Disord. 2019 Feb;59:140-145. doi: 10.1016/j.parkreldis.2019.02.016. Epub 2019 Feb 14. Parkinsonism Relat Disord. 2019. PMID: 30797706 Review.
Pharmacologic treatments need to be life-long and are focused on restoration of negative copper balance without inducing iatrogenic copper deficiency. The gold standard of therapy is chelation of excessive copper. ...We also review most promising novel therapeutic approach …
Pharmacologic treatments need to be life-long and are focused on restoration of negative copper balance without inducing iatrogenic copper …
156 results