Degrado WF - Search Results

1

A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein.

Polishchuk AL, Lear JD, Ma C, Lamb RA, Pinto LH, Degrado WF. Polishchuk AL, et al. Among authors: degrado wf. Biochemistry. 2010 Nov 30;49(47):10061-71. doi: 10.1021/bi101229m. Epub 2010 Nov 3. Biochemistry. 2010. PMID: 20968306 Free PMC article.

2

Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy.

Li R, Babu CR, Valentine K, Lear JD, Wand AJ, Bennett JS, DeGrado WF. Li R, et al. Among authors: degrado wf. Biochemistry. 2002 Dec 31;41(52):15618-24. doi: 10.1021/bi026822l. Biochemistry. 2002. PMID: 12501190

3

Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function.

Stouffer AL, Nanda V, Lear JD, DeGrado WF. Stouffer AL, et al. Among authors: degrado wf. J Mol Biol. 2005 Mar 18;347(1):169-79. doi: 10.1016/j.jmb.2005.01.023. Epub 2005 Jan 21. J Mol Biol. 2005. PMID: 15733926

4

The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus.

Stouffer AL, Ma C, Cristian L, Ohigashi Y, Lamb RA, Lear JD, Pinto LH, DeGrado WF. Stouffer AL, et al. Among authors: degrado wf. Structure. 2008 Jul;16(7):1067-76. doi: 10.1016/j.str.2008.04.011. Structure. 2008. PMID: 18611380 Free PMC article.

5

pH-induced conformational change of the influenza M2 protein C-terminal domain.

Nguyen PA, Soto CS, Polishchuk A, Caputo GA, Tatko CD, Ma C, Ohigashi Y, Pinto LH, DeGrado WF, Howard KP. Nguyen PA, et al. Among authors: degrado wf. Biochemistry. 2008 Sep 23;47(38):9934-6. doi: 10.1021/bi801315m. Epub 2008 Aug 29. Biochemistry. 2008. PMID: 18754675 Free PMC article.

6

Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus.

Wang J, Cady SD, Balannik V, Pinto LH, DeGrado WF, Hong M. Wang J, et al. Among authors: degrado wf. J Am Chem Soc. 2009 Jun 17;131(23):8066-76. doi: 10.1021/ja900063s. J Am Chem Soc. 2009. PMID: 19469531 Free PMC article.

7

Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus.

Balannik V, Wang J, Ohigashi Y, Jing X, Magavern E, Lamb RA, Degrado WF, Pinto LH. Balannik V, et al. Among authors: degrado wf. Biochemistry. 2009 Dec 22;48(50):11872-82. doi: 10.1021/bi9014488. Biochemistry. 2009. PMID: 19905033 Free PMC article.

8

Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel.

Balannik V, Carnevale V, Fiorin G, Levine BG, Lamb RA, Klein ML, Degrado WF, Pinto LH. Balannik V, et al. Among authors: degrado wf. Biochemistry. 2010 Feb 2;49(4):696-708. doi: 10.1021/bi901799k. Biochemistry. 2010. PMID: 20028125 Free PMC article.

9

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus.

Acharya R, Carnevale V, Fiorin G, Levine BG, Polishchuk AL, Balannik V, Samish I, Lamb RA, Pinto LH, DeGrado WF, Klein ML. Acharya R, et al. Among authors: degrado wf. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15075-80. doi: 10.1073/pnas.1007071107. Epub 2010 Aug 5. Proc Natl Acad Sci U S A. 2010. PMID: 20689043 Free PMC article.

10

Photoinduced electron transfer and fluorophore motion as a probe of the conformational dynamics of membrane proteins: application to the influenza a M2 proton channel.

Rogers JM, Polishchuk AL, Guo L, Wang J, DeGrado WF, Gai F. Rogers JM, et al. Among authors: degrado wf. Langmuir. 2011 Apr 5;27(7):3815-21. doi: 10.1021/la200480d. Epub 2011 Mar 14. Langmuir. 2011. PMID: 21401044 Free PMC article.

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