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The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis.
Elg M, Gustafsson D, Deinum J. Elg M, et al. Among authors: deinum j. Thromb Haemost. 1997 Oct;78(4):1286-92. Thromb Haemost. 1997. PMID: 9364999
Characterization of thrombin derived from human recombinant prothrombin.
Lövgren A, Deinum J, Rosén S, Bryngelhed P, Rosén P, Hansson KM. Lövgren A, et al. Among authors: deinum j. Blood Coagul Fibrinolysis. 2015 Jul;26(5):545-55. doi: 10.1097/MBC.0000000000000289. Blood Coagul Fibrinolysis. 2015. PMID: 25811451 Free PMC article.
A serendipitously identified novel small molecule procoagulant compound giving rise to a high-throughput screening assay based on human plasma.
Gustafsson D, Nielsen S, McPheat J, Wågberg F, Kaspersson K, Rohman M, Ulander J, Fex T, Fjellström O, Deinum J. Gustafsson D, et al. Among authors: deinum j. Thromb Res. 2013 Aug;132(2):248-55. doi: 10.1016/j.thromres.2013.05.023. Epub 2013 Jul 3. Thromb Res. 2013. PMID: 23830061
Addition of prothrombin to plasma can result in a paradoxical increase in activated partial thromboplastin time.
Hansson KM, Björkqvist J, Deinum J. Hansson KM, et al. Among authors: deinum j. Blood Coagul Fibrinolysis. 2014 Dec;25(8):851-5. doi: 10.1097/MBC.0000000000000161. Blood Coagul Fibrinolysis. 2014. PMID: 25004021
Identification of structural-kinetic and structural-thermodynamic relationships for thrombin inhibitors.
Winquist J, Geschwindner S, Xue Y, Gustavsson L, Musil D, Deinum J, Danielson UH. Winquist J, et al. Among authors: deinum j. Biochemistry. 2013 Jan 29;52(4):613-26. doi: 10.1021/bi301333z. Epub 2013 Jan 16. Biochemistry. 2013. PMID: 23290007
Biochemical and pharmacological effects of the direct thrombin inhibitor AR-H067637.
Deinum J, Mattsson C, Inghardt T, Elg M. Deinum J, et al. Thromb Haemost. 2009 Jun;101(6):1051-9. Thromb Haemost. 2009. PMID: 19492147
A thermodynamic characterization of the binding of thrombin inhibitors to human thrombin, combining biosensor technology, stopped-flow spectrophotometry, and microcalorimetry.
Deinum J, Gustavsson L, Gyzander E, Kullman-Magnusson M, Edström A, Karlsson R. Deinum J, et al. Anal Biochem. 2002 Jan 15;300(2):152-62. doi: 10.1006/abio.2001.5454. Anal Biochem. 2002. PMID: 11779106
Characterisation of novel indenoindoles. Part II. Redox-recycling with ascorbate.
Björquist P, Deinum J, Taure K, Westerlund C, Ostlund-Lindqvist AM. Björquist P, et al. Among authors: deinum j. Biochem Pharmacol. 1996 May 17;51(10):1403-10. doi: 10.1016/0006-2952(96)00079-2. Biochem Pharmacol. 1996. PMID: 8787558
Effect of different types of thrombin inhibitors on thrombin/thrombomodulin modulated activation of protein C in vitro.
Mattsson C, Menschik-Lundin A, Nylander S, Gyzander E, Deinum J. Mattsson C, et al. Among authors: deinum j. Thromb Res. 2001 Dec 15;104(6):475-86. doi: 10.1016/s0049-3848(01)00392-9. Thromb Res. 2001. PMID: 11755958
Plasminogen activator inhibitor type-1 interacts exclusively with the proteinase domain of tissue plasminogen activator.
Björquist P, Brohlin M, Ehnebom J, Ericsson M, Kristiansen C, Pohl G, Deinum J. Björquist P, et al. Among authors: deinum j. Biochim Biophys Acta. 1994 Dec 14;1209(2):191-202. doi: 10.1016/0167-4838(94)90184-8. Biochim Biophys Acta. 1994. PMID: 7811690
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