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The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.
de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A. de Thé H, et al. Among authors: dejean a. Cell. 1991 Aug 23;66(4):675-84. doi: 10.1016/0092-8674(91)90113-d. Cell. 1991. PMID: 1652369
We report here that this gene product contains a novel zinc finger motif common to several DNA-binding proteins. The PML-RAR alpha mRNA encodes a predicted 106 kd chimeric protein containing most of the PML sequences fused to a large part of RAR alpha, includ …
We report here that this gene product contains a novel zinc finger motif common to several DNA-binding proteins. The PML-RAR alpha mR …
A t(3;8) chromosomal translocation associated with hepatitis B virus intergration involves the carboxypeptidase N locus.
Pineau P, Marchio A, Terris B, Mattei MG, Tu ZX, Tiollais P, Dejean A. Pineau P, et al. Among authors: dejean a. J Virol. 1996 Oct;70(10):7280-4. doi: 10.1128/JVI.70.10.7280-7284.1996. J Virol. 1996. PMID: 8794383 Free PMC article.
Here, we report a t(3;8) chromosomal translocation present in a hepatocellular carcinoma developed in noncirrhotic liver tissue. ...The present data strongly support a model in which HBV-induced chromosomal rearrangements play a key role during multist …
Here, we report a t(3;8) chromosomal translocation present in a hepatocellular carcinoma developed in noncirrhotic liver tissu …
The PML nuclear bodies: actors or extras?
Seeler JS, Dejean A. Seeler JS, et al. Among authors: dejean a. Curr Opin Genet Dev. 1999 Jun;9(3):362-7. doi: 10.1016/s0959-437x(99)80054-9. Curr Opin Genet Dev. 1999. PMID: 10377280 Review.
The PML and SP100-containing nuclear bodies (NBs) represent the best-studied example of a defined nuclear substructure the integrity of which is compromised in certain human diseases, including leukemia, neurodegenerative disorders and viral infection. Although recent prog …
The PML and SP100-containing nuclear bodies (NBs) represent the best-studied example of a defined nuclear substructure the integrity …
Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption.
Müller S, Dejean A. Müller S, et al. Among authors: dejean a. J Virol. 1999 Jun;73(6):5137-43. doi: 10.1128/JVI.73.6.5137-5143.1999. J Virol. 1999. PMID: 10233977 Free PMC article.
Infection by a number of DNA viruses similarly triggers the reorganization of these structures, suggesting an important role for the NBs in the viral infection process. While expression of the adenovirus E4 ORF3 protein leads to only a moderate redistribution of PML …
Infection by a number of DNA viruses similarly triggers the reorganization of these structures, suggesting an important role for the …
Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells.
Müller S, Miller WH Jr, Dejean A. Müller S, et al. Among authors: dejean a. Blood. 1998 Dec 1;92(11):4308-16. Blood. 1998. PMID: 9834237
The resulting PML-RAR protein induces a block in the differentiation of the myeloid progenitor cells, which can be released by retinoic acid (RA) in vitro and in vivo. ...From these data, we propose that, in analogy to As2O3, antimonials might have a beneficial ther …
The resulting PML-RAR protein induces a block in the differentiation of the myeloid progenitor cells, which can be released by retino …
Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus.
Müller S, Matunis MJ, Dejean A. Müller S, et al. Among authors: dejean a. EMBO J. 1998 Jan 2;17(1):61-70. doi: 10.1093/emboj/17.1.61. EMBO J. 1998. PMID: 9427741 Free PMC article.
In non-APL cells, the ubiquitin-like protein SUMO-1 is covalently attached to a subset of wild-type PML in a reversible and phosphorylation-dependent manner. ...They provide additional evidence that the role of 'ubiquitin-like' post-translational modification is not …
In non-APL cells, the ubiquitin-like protein SUMO-1 is covalently attached to a subset of wild-type PML in a reversible and ph …
Molecular cloning of a new interferon-induced PML nuclear body-associated protein.
Gongora C, David G, Pintard L, Tissot C, Hua TD, Dejean A, Mechti N. Gongora C, et al. Among authors: dejean a. J Biol Chem. 1997 Aug 1;272(31):19457-63. doi: 10.1074/jbc.272.31.19457. J Biol Chem. 1997. PMID: 9235947
We have established a cDNA library from human lymphoblastoid Daudi cells treated for 16 h with human alpha/beta-interferon (IFN) and made use of differential screening to search for as yet unidentified IFN-regulated genes. In the course of this study, we have isolated a
We have established a cDNA library from human lymphoblastoid Daudi cells treated for 16 h with human alpha/beta-interferon (IFN) and …
Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells.
Weis K, Rambaud S, Lavau C, Jansen J, Carvalho T, Carmo-Fonseca M, Lamond A, Dejean A. Weis K, et al. Among authors: dejean a. Cell. 1994 Jan 28;76(2):345-56. doi: 10.1016/0092-8674(94)90341-7. Cell. 1994. PMID: 8293468
Acute promyelocytic leukemia (APL) is characterized by a specific t(15;17) translocation that fuses the retinoic acid receptor alpha (RAR alpha) to a novel gene product, PML. ...This suggests that the hybrid could exert a dominant negative effect by diverting …
Acute promyelocytic leukemia (APL) is characterized by a specific t(15;17) translocation that fuses the retinoic acid receptor alpha …
Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.
Carvalho T, Seeler JS, Ohman K, Jordan P, Pettersson U, Akusjärvi G, Carmo-Fonseca M, Dejean A. Carvalho T, et al. Among authors: dejean a. J Cell Biol. 1995 Oct;131(1):45-56. doi: 10.1083/jcb.131.1.45. J Cell Biol. 1995. PMID: 7559785 Free PMC article.
Here we report that adenovirus infection causes a drastic redistribution of PML from spherical nuclear bodies into fibrous structures. ...Taken together, the present data indicate that the subnuclear domains containing PML represent a preferential target for DNA tum …
Here we report that adenovirus infection causes a drastic redistribution of PML from spherical nuclear bodies into fibrous structures …
Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways.
Jansen JH, Mahfoudi A, Rambaud S, Lavau C, Wahli W, Dejean A. Jansen JH, et al. Among authors: dejean a. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7401-5. doi: 10.1073/pnas.92.16.7401. Proc Natl Acad Sci U S A. 1995. PMID: 7638205 Free PMC article.
We show that endogenous PML-RAR alpha can bind to DNA as a homodimer, in contrast to RAR alpha that requires the retinoid X receptor (RXR) dimerization partner. ...Treatment with retinoic acid results in a decrease of PML-RAR alpha protein levels and, as a co …
We show that endogenous PML-RAR alpha can bind to DNA as a homodimer, in contrast to RAR alpha that requires the retinoid X receptor …
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