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Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography.
Nyúl-Tóth Á, Tarantini S, DelFavero J, Yan F, Balasubramanian P, Yabluchanskiy A, Ahire C, Kiss T, Csipo T, Lipecz A, Farkas AE, Wilhelm I, Krizbai IA, Tang Q, Csiszar A, Ungvari Z. Nyúl-Tóth Á, et al. Among authors: delfavero j. Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1370-H1392. doi: 10.1152/ajpheart.00709.2020. Epub 2021 Feb 5. Am J Physiol Heart Circ Physiol. 2021. PMID: 33543687 Free PMC article.
Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging.
Tarantini S, Yabluchanskiy A, Csipo T, Fulop G, Kiss T, Balasubramanian P, DelFavero J, Ahire C, Ungvari A, Nyúl-Tóth Á, Farkas E, Benyo Z, Tóth A, Csiszar A, Ungvari Z. Tarantini S, et al. Among authors: delfavero j. Geroscience. 2019 Oct;41(5):533-542. doi: 10.1007/s11357-019-00101-2. Epub 2019 Nov 2. Geroscience. 2019. PMID: 31679124 Free PMC article.
Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice.
Yabluchanskiy A, Tarantini S, Balasubramanian P, Kiss T, Csipo T, Fülöp GA, Lipecz A, Ahire C, DelFavero J, Nyul-Toth A, Sonntag WE, Schwartzman ML, Campisi J, Csiszar A, Ungvari Z. Yabluchanskiy A, et al. Among authors: delfavero j. Geroscience. 2020 Apr;42(2):409-428. doi: 10.1007/s11357-020-00154-8. Epub 2020 Jan 20. Geroscience. 2020. PMID: 31960269 Free PMC article.
CD82-TRPM7-Numb signaling mediates age-related cognitive impairment.
Zhao Y, Kiss T, DelFavero J, Li L, Li X, Zheng L, Wang J, Jiang C, Shi J, Ungvari Z, Csiszar A, Zhang XA. Zhao Y, et al. Among authors: delfavero j. Geroscience. 2020 Apr;42(2):595-611. doi: 10.1007/s11357-020-00166-4. Epub 2020 Feb 22. Geroscience. 2020. PMID: 32088828 Free PMC article.
Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice.
Tarantini S, Balasubramanian P, Delfavero J, Csipo T, Yabluchanskiy A, Kiss T, Nyúl-Tóth Á, Mukli P, Toth P, Ahire C, Ungvari A, Benyo Z, Csiszar A, Ungvari Z. Tarantini S, et al. Among authors: delfavero j. Geroscience. 2021 Oct;43(5):2427-2440. doi: 10.1007/s11357-021-00440-z. Epub 2021 Aug 24. Geroscience. 2021. PMID: 34427858 Free PMC article.
The aging venous system: from varicosities to vascular cognitive impairment.
Molnár AÁ, Nádasy GL, Dörnyei G, Patai BB, Delfavero J, Fülöp GÁ, Kirkpatrick AC, Ungvári Z, Merkely B. Molnár AÁ, et al. Among authors: delfavero j. Geroscience. 2021 Dec;43(6):2761-2784. doi: 10.1007/s11357-021-00475-2. Epub 2021 Nov 11. Geroscience. 2021. PMID: 34762274 Free PMC article. Review.
Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain.
Kiss T, Nyúl-Tóth Á, DelFavero J, Balasubramanian P, Tarantini S, Faakye J, Gulej R, Ahire C, Ungvari A, Yabluchanskiy A, Wiley G, Garman L, Ungvari Z, Csiszar A. Kiss T, et al. Among authors: delfavero j. Geroscience. 2022 Apr;44(2):661-681. doi: 10.1007/s11357-022-00521-7. Epub 2022 Jan 31. Geroscience. 2022. PMID: 35098444 Free PMC article.
158 results