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Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
Mackman RL, Mish M, Chin G, Perry JK, Appleby T, Aktoudianakis V, Metobo S, Pyun P, Niu C, Daffis S, Yu H, Zheng J, Villasenor AG, Zablocki J, Chamberlain J, Jin H, Lee G, Suekawa-Pirrone K, Santos R, Delaney WE 4th, Fletcher SP. Mackman RL, et al. Among authors: delaney we 4th. J Med Chem. 2020 Sep 24;63(18):10188-10203. doi: 10.1021/acs.jmedchem.0c00100. Epub 2020 Jun 3. J Med Chem. 2020. PMID: 32407112
Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B.
Daffis S, Balsitis S, Chamberlain J, Zheng J, Santos R, Rowe W, Ramakrishnan D, Pattabiraman D, Spurlock S, Chu R, Kang D, Mish M, Ramirez R, Li L, Li B, Ma S, Hung M, Voitenleitner C, Yon C, Suresh M, Menne S, Cote P, Delaney WE 4th, Mackman R, Fletcher SP. Daffis S, et al. Among authors: delaney we 4th. Hepatology. 2020 Apr 4. doi: 10.1002/hep.31255. Online ahead of print. Hepatology. 2020. PMID: 32246499
Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism.
Niu C, Li L, Daffis S, Lucifora J, Bonnin M, Maadadi S, Salas E, Chu R, Ramos H, Livingston CM, Beran RK, Garg AV, Balsitis S, Durantel D, Zoulim F, Delaney WE 4th, Fletcher SP. Niu C, et al. Among authors: delaney we 4th. J Hepatol. 2018 May;68(5):922-931. doi: 10.1016/j.jhep.2017.12.007. Epub 2017 Dec 13. J Hepatol. 2018. PMID: 29247725
Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells.
Li L, Barry V, Daffis S, Niu C, Huntzicker E, French DM, Mikaelian I, Lanford RE, Delaney WE 4th, Fletcher SP. Li L, et al. Among authors: delaney we 4th. J Hepatol. 2018 May;68(5):912-921. doi: 10.1016/j.jhep.2017.12.008. Epub 2017 Dec 14. J Hepatol. 2018. PMID: 29247724
Development of a digital droplet PCR assay to measure HBV DNA in patients receiving long-term TDF treatment.
Liu Y, Cathcart AL, Delaney WE 4th, Kitrinos KM. Liu Y, et al. Among authors: delaney we 4th. J Virol Methods. 2017 Nov;249:189-193. doi: 10.1016/j.jviromet.2017.09.015. Epub 2017 Sep 18. J Virol Methods. 2017. PMID: 28923315
Preclinical characterization of the novel HCV NS3 protease inhibitor GS-9256.
Yang H, Yang C, Wang Y, Rhodes G, Robinson M, Cheng G, Qi X, Mo H, Tian Y, Pakdaman R, Sheng XC, Kim CU, Delaney WE 4th. Yang H, et al. Among authors: delaney we 4th. Antivir Ther. 2017;22(5):413-420. doi: 10.3851/IMP3132. Epub 2017 Jan 20. Antivir Ther. 2017. PMID: 28106531
Cell-Free Hepatitis B Virus Capsid Assembly Dependent on the Core Protein C-Terminal Domain and Regulated by Phosphorylation.
Ludgate L, Liu K, Luckenbaugh L, Streck N, Eng S, Voitenleitner C, Delaney WE 4th, Hu J. Ludgate L, et al. Among authors: delaney we 4th. J Virol. 2016 May 27;90(12):5830-5844. doi: 10.1128/JVI.00394-16. Print 2016 Jun 15. J Virol. 2016. PMID: 27076641 Free PMC article.
Genome-free hepatitis B virion levels in patient sera as a potential marker to monitor response to antiviral therapy.
Luckenbaugh L, Kitrinos KM, Delaney WE 4th, Hu J. Luckenbaugh L, et al. Among authors: delaney we 4th. J Viral Hepat. 2015 Jun;22(6):561-70. doi: 10.1111/jvh.12361. Epub 2014 Nov 14. J Viral Hepat. 2015. PMID: 25395045 Free PMC article.
Binding kinetics, potency, and selectivity of the hepatitis C virus NS3 protease inhibitors GS-9256 and vedroprevir.
Barauskas O, Corsa AC, Wang R, Hluhanich S, Jin D, Hung M, Yang H, Delaney WE 4th, Schultz BE. Barauskas O, et al. Among authors: delaney we 4th. Biochim Biophys Acta. 2014 Dec;1840(12):3292-8. doi: 10.1016/j.bbagen.2014.08.002. Epub 2014 Aug 17. Biochim Biophys Acta. 2014. PMID: 25139683
A small-molecule inhibitor of hepatitis C virus infectivity.
Bush CO, Pokrovskii MV, Saito R, Morganelli P, Canales E, Clarke MO, Lazerwith SE, Golde J, Reid BG, Babaoglu K, Pagratis N, Zhong W, Delaney WE 4th, Paulson MS, Beran RK. Bush CO, et al. Among authors: delaney we 4th. Antimicrob Agents Chemother. 2014;58(1):386-96. doi: 10.1128/AAC.02083-13. Epub 2013 Oct 28. Antimicrob Agents Chemother. 2014. PMID: 24165192 Free PMC article.
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