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Neuronal PTP1B regulates body weight, adiposity and leptin action.
Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Bence KK, et al. Nat Med. 2006 Aug;12(8):917-24. doi: 10.1038/nm1435. Epub 2006 Jul 16. Nat Med. 2006. PMID: 16845389
Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.
Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB. Xue B, et al. Mol Cell Biol. 2009 Aug;29(16):4563-73. doi: 10.1128/MCB.01914-08. Epub 2009 Jun 15. Mol Cell Biol. 2009. PMID: 19528236 Free PMC article.
Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.
Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK. Delibegovic M, et al. Diabetes. 2009 Mar;58(3):590-9. doi: 10.2337/db08-0913. Epub 2008 Dec 15. Diabetes. 2009. PMID: 19074988 Free PMC article.
Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.
Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, Neel BG. Delibegovic M, et al. Mol Cell Biol. 2007 Nov;27(21):7727-34. doi: 10.1128/MCB.00959-07. Epub 2007 Aug 27. Mol Cell Biol. 2007. PMID: 17724080 Free PMC article.
Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction.
Agouni A, Tual-Chalot S, Chalopin M, Duluc L, Mody N, Martinez MC, Andriantsitohaina R, Delibegović M. Agouni A, et al. Biochem Pharmacol. 2014 Dec 15;92(4):607-17. doi: 10.1016/j.bcp.2014.10.008. Epub 2014 Oct 30. Biochem Pharmacol. 2014. PMID: 25451690
Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice.
Owen C, Lees EK, Grant L, Zimmer DJ, Mody N, Bence KK, Delibegović M. Owen C, et al. Diabetologia. 2013 Oct;56(10):2286-96. doi: 10.1007/s00125-013-2992-z. Epub 2013 Jul 6. Diabetologia. 2013. PMID: 23832083
Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees EK, Mcilroy GD, Göransson O, Welch A, Bence KK, Kahn BB, Neel BG, Mody N, Delibegović M. Owen C, et al. PLoS One. 2012;7(2):e32700. doi: 10.1371/journal.pone.0032700. Epub 2012 Feb 28. PLoS One. 2012. PMID: 22389718 Free PMC article.
Neuronal human BACE1 knockin induces systemic diabetes in mice.
Plucińska K, Dekeryte R, Koss D, Shearer K, Mody N, Whitfield PD, Doherty MK, Mingarelli M, Welch A, Riedel G, Delibegovic M, Platt B. Plucińska K, et al. Diabetologia. 2016 Jul;59(7):1513-1523. doi: 10.1007/s00125-016-3960-1. Epub 2016 May 2. Diabetologia. 2016. PMID: 27138913 Free PMC article.
Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanism.
Grant L, Shearer KD, Czopek A, Lees EK, Owen C, Agouni A, Workman J, Martin-Granados C, Forrester JV, Wilson HM, Mody N, Delibegovic M. Grant L, et al. Diabetes. 2014 Feb;63(2):456-70. doi: 10.2337/db13-0885. Epub 2013 Nov 1. Diabetes. 2014. PMID: 24186864
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