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Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
Leung IK, Demetriades M, Hardy AP, Lejeune C, Smart TJ, Szöllössi A, Kawamura A, Schofield CJ, Claridge TD. Leung IK, et al. Among authors: demetriades m. J Med Chem. 2013 Jan 24;56(2):547-55. doi: 10.1021/jm301583m. Epub 2013 Jan 4. J Med Chem. 2013. PMID: 23234607 Free PMC article.
Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.
Shishodia S, Demetriades M, Zhang D, Tam NY, Maheswaran P, Clunie-O'Connor C, Tumber A, Leung IKH, Ng YM, Leissing TM, El-Sagheer AH, Salah E, Brown T, Aik WS, McDonough MA, Schofield CJ. Shishodia S, et al. Among authors: demetriades m. J Med Chem. 2021 Nov 25;64(22):16609-16625. doi: 10.1021/acs.jmedchem.1c01204. Epub 2021 Nov 11. J Med Chem. 2021. PMID: 34762429 Free PMC article.
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
Yeoh KK, Chan MC, Thalhammer A, Demetriades M, Chowdhury R, Tian YM, Stolze I, McNeill LA, Lee MK, Woon ECY, Mackeen MM, Kawamura A, Ratcliffe PJ, Mecinović J, Schofield CJ. Yeoh KK, et al. Among authors: demetriades m. Org Biomol Chem. 2013 Feb 7;11(5):732-745. doi: 10.1039/c2ob26648b. Epub 2012 Nov 15. Org Biomol Chem. 2013. PMID: 23151668 Free PMC article.
Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A, Demetriades M, Mathavan S, Kawamura A, Lee MK, van Eeden F, Pugh CW, Ratcliffe PJ, Schofield CJ. Chowdhury R, et al. Among authors: demetriades m. ACS Chem Biol. 2013 Jul 19;8(7):1488-96. doi: 10.1021/cb400088q. Epub 2013 Jun 12. ACS Chem Biol. 2013. PMID: 23683440
On the histone lysine methyltransferase activity of fungal metabolite chaetocin.
Cherblanc FL, Chapman KL, Reid J, Borg AJ, Sundriyal S, Alcazar-Fuoli L, Bignell E, Demetriades M, Schofield CJ, DiMaggio PA Jr, Brown R, Fuchter MJ. Cherblanc FL, et al. Among authors: demetriades m. J Med Chem. 2013 Nov 14;56(21):8616-25. doi: 10.1021/jm401063r. Epub 2013 Oct 25. J Med Chem. 2013. PMID: 24099080
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.
Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V, Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura A, Pugh CW, Ratcliffe PJ, Schofield CJ. Chan MC, et al. Among authors: demetriades m. PLoS One. 2015 Jul 6;10(7):e0132004. doi: 10.1371/journal.pone.0132004. eCollection 2015. PLoS One. 2015. PMID: 26147748 Free PMC article.
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