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21 results
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The signaling adaptors and pathways activated by TNF superfamily.
Dempsey PW, Doyle SE, He JQ, Cheng G. Dempsey PW, et al. Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):193-209. doi: 10.1016/s1359-6101(03)00021-2. Cytokine Growth Factor Rev. 2003. PMID: 12787559 Review.
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.
Razani B, Zarnegar B, Ytterberg AJ, Shiba T, Dempsey PW, Ware CF, Loo JA, Cheng G. Razani B, et al. Among authors: dempsey pw. Sci Signal. 2010 May 25;3(123):ra41. doi: 10.1126/scisignal.2000778. Sci Signal. 2010. PMID: 20501937 Free PMC article.
Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance.
Chin AI, Miyahira AK, Covarrubias A, Teague J, Guo B, Dempsey PW, Cheng G. Chin AI, et al. Among authors: dempsey pw. Cancer Res. 2010 Apr 1;70(7):2595-603. doi: 10.1158/0008-5472.CAN-09-1162. Epub 2010 Mar 16. Cancer Res. 2010. PMID: 20233880 Free PMC article.
Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses.
Liu PT, Schenk M, Walker VP, Dempsey PW, Kanchanapoomi M, Wheelwright M, Vazirnia A, Zhang X, Steinmeyer A, Z├╝gel U, Hollis BW, Cheng G, Modlin RL. Liu PT, et al. Among authors: dempsey pw. PLoS One. 2009 Jun 5;4(6):e5810. doi: 10.1371/journal.pone.0005810. PLoS One. 2009. PMID: 19503839 Free PMC article.
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.
Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J, Shiba T, Yang X, Yeh WC, Mak TW, Korneluk RG, Cheng G. Zarnegar BJ, et al. Among authors: dempsey pw. Nat Immunol. 2008 Dec;9(12):1371-8. doi: 10.1038/ni.1676. Epub 2008 Nov 9. Nat Immunol. 2008. PMID: 18997794 Free PMC article.
Rescue of TRAF3-null mice by p100 NF-kappa B deficiency.
He JQ, Zarnegar B, Oganesyan G, Saha SK, Yamazaki S, Doyle SE, Dempsey PW, Cheng G. He JQ, et al. Among authors: dempsey pw. J Exp Med. 2006 Oct 30;203(11):2413-8. doi: 10.1084/jem.20061166. Epub 2006 Oct 2. J Exp Med. 2006. PMID: 17015635 Free PMC article.
Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1.
O'Connell RM, Vaidya SA, Perry AK, Saha SK, Dempsey PW, Cheng G. O'Connell RM, et al. Among authors: dempsey pw. J Immunol. 2005 Feb 1;174(3):1602-7. doi: 10.4049/jimmunol.174.3.1602. J Immunol. 2005. PMID: 15661922
PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity.
Liu B, Mink S, Wong KA, Stein N, Getman C, Dempsey PW, Wu H, Shuai K. Liu B, et al. Among authors: dempsey pw. Nat Immunol. 2004 Sep;5(9):891-8. doi: 10.1038/ni1104. Epub 2004 Aug 15. Nat Immunol. 2004. PMID: 15311277
Involvement of receptor-interacting protein 2 in innate and adaptive immune responses.
Chin AI, Dempsey PW, Bruhn K, Miller JF, Xu Y, Cheng G. Chin AI, et al. Among authors: dempsey pw. Nature. 2002 Mar 14;416(6877):190-4. doi: 10.1038/416190a. Nature. 2002. PMID: 11894097
IRF3 mediates a TLR3/TLR4-specific antiviral gene program.
Doyle S, Vaidya S, O'Connell R, Dadgostar H, Dempsey P, Wu T, Rao G, Sun R, Haberland M, Modlin R, Cheng G. Doyle S, et al. Immunity. 2002 Sep;17(3):251-63. doi: 10.1016/s1074-7613(02)00390-4. Immunity. 2002. PMID: 12354379
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