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A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis.
Chen L, Li D, Li C, Engel A, Deng CX. Chen L, et al. Among authors: deng cx. Bone. 2003 Aug;33(2):169-78. doi: 10.1016/s8756-3282(03)00222-9. Bone. 2003. PMID: 14499350
Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis.
Zhao M, Li D, Shimazu K, Zhou YX, Lu B, Deng CX. Zhao M, et al. Among authors: deng cx. Biol Psychiatry. 2007 Sep 1;62(5):381-90. doi: 10.1016/j.biopsych.2006.10.019. Epub 2007 Jan 18. Biol Psychiatry. 2007. PMID: 17239352
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
Wang RH, Kim HS, Xiao C, Xu X, Gavrilova O, Deng CX. Wang RH, et al. Among authors: deng cx. J Clin Invest. 2011 Nov;121(11):4477-90. doi: 10.1172/JCI46243. Epub 2011 Oct 3. J Clin Invest. 2011. PMID: 21965330 Free PMC article.
Bmi1 regulates mitochondrial function and the DNA damage response pathway.
Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, Xu XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T. Liu J, et al. Among authors: deng cx. Nature. 2009 May 21;459(7245):387-392. doi: 10.1038/nature08040. Epub 2009 Apr 29. Nature. 2009. PMID: 19404261 Free PMC article.
IGF signaling pathway as a selective target of familial breast cancer therapy.
Shukla V, Coumoul X, Vassilopoulos A, Deng CX. Shukla V, et al. Among authors: deng cx. Curr Mol Med. 2008 Dec;8(8):727-40. doi: 10.2174/156652408786733694. Curr Mol Med. 2008. PMID: 19075671 Review.
SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation.
Wang RH, Xu X, Kim HS, Xiao Z, Deng CX. Wang RH, et al. Among authors: deng cx. Int J Biol Sci. 2013 Sep 21;9(9):934-46. doi: 10.7150/ijbs.7529. eCollection 2013. Int J Biol Sci. 2013. PMID: 24163589 Free PMC article.
Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice.
Xiao C, Wang RH, Lahusen TJ, Park O, Bertola A, Maruyama T, Reynolds D, Chen Q, Xu X, Young HA, Chen WJ, Gao B, Deng CX. Xiao C, et al. Among authors: deng cx. J Biol Chem. 2012 Dec 7;287(50):41903-13. doi: 10.1074/jbc.M112.415182. Epub 2012 Oct 16. J Biol Chem. 2012. PMID: 23076146 Free PMC article.
Anterior visceral endoderm SMAD4 signaling specifies anterior embryonic patterning and head induction in mice.
Li C, Li YP, Fu XY, Deng CX. Li C, et al. Among authors: deng cx. Int J Biol Sci. 2010 Sep 27;6(6):569-83. doi: 10.7150/ijbs.6.569. Int J Biol Sci. 2010. PMID: 20941375 Free PMC article.
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.
Xiao C, Kim HS, Lahusen T, Wang RH, Xu X, Gavrilova O, Jou W, Gius D, Deng CX. Xiao C, et al. Among authors: deng cx. J Biol Chem. 2010 Nov 19;285(47):36776-84. doi: 10.1074/jbc.M110.168039. Epub 2010 Sep 16. J Biol Chem. 2010. PMID: 20847051 Free PMC article.
RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis.
Shukla V, Coumoul X, Wang RH, Kim HS, Deng CX. Shukla V, et al. Among authors: deng cx. Nat Genet. 2007 Sep;39(9):1145-50. doi: 10.1038/ng2096. Epub 2007 Aug 12. Nat Genet. 2007. PMID: 17694057
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