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A JNK-dependent pathway is required for TNFalpha-induced apoptosis.
Deng Y, Ren X, Yang L, Lin Y, Wu X. Deng Y, et al. Cell. 2003 Oct 3;115(1):61-70. doi: 10.1016/s0092-8674(03)00757-8. Cell. 2003. PMID: 14532003
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.
Buis J, Wu Y, Deng Y, Leddon J, Westfield G, Eckersdorff M, Sekiguchi JM, Chang S, Ferguson DO. Buis J, et al. Among authors: deng y. Cell. 2008 Oct 3;135(1):85-96. doi: 10.1016/j.cell.2008.08.015. Cell. 2008. PMID: 18854157 Free PMC article.
Bax and BH3-domain-only proteins in p53-mediated apoptosis.
Wu X, Deng Y. Wu X, et al. Among authors: deng y. Front Biosci. 2002 Jan 1;7:d151-6. Front Biosci. 2002. PMID: 11779719 Review.
Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth.
Wang L, Xiong H, Wu F, Zhang Y, Wang J, Zhao L, Guo X, Chang LJ, Zhang Y, You MJ, Koochekpour S, Saleem M, Huang H, Lu J, Deng Y. Wang L, et al. Among authors: deng y. Cell Rep. 2014 Sep 11;8(5):1461-74. doi: 10.1016/j.celrep.2014.07.053. Epub 2014 Aug 28. Cell Rep. 2014. PMID: 25176644 Free PMC article.
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.
Guo X, Deng Y, Lin Y, Cosme-Blanco W, Chan S, He H, Yuan G, Brown EJ, Chang S. Guo X, et al. Among authors: deng y. EMBO J. 2007 Nov 14;26(22):4709-19. doi: 10.1038/sj.emboj.7601893. Epub 2007 Oct 18. EMBO J. 2007. PMID: 17948054 Free PMC article.
Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.
Wu L, Multani AS, He H, Cosme-Blanco W, Deng Y, Deng JM, Bachilo O, Pathak S, Tahara H, Bailey SM, Deng Y, Behringer RR, Chang S. Wu L, et al. Among authors: deng y, deng jm, deng y. Cell. 2006 Jul 14;126(1):49-62. doi: 10.1016/j.cell.2006.05.037. Cell. 2006. PMID: 16839876
Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita.
He H, Wang Y, Guo X, Ramchandani S, Ma J, Shen MF, Garcia DA, Deng Y, Multani AS, You MJ, Chang S. He H, et al. Among authors: deng y. Mol Cell Biol. 2009 Jan;29(1):229-40. doi: 10.1128/MCB.01400-08. Epub 2008 Oct 20. Mol Cell Biol. 2009. PMID: 18936156 Free PMC article.
POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination.
He H, Multani AS, Cosme-Blanco W, Tahara H, Ma J, Pathak S, Deng Y, Chang S. He H, et al. Among authors: deng y. EMBO J. 2006 Nov 1;25(21):5180-90. doi: 10.1038/sj.emboj.7601294. Epub 2006 Oct 19. EMBO J. 2006. PMID: 17053789 Free PMC article.
Role of telomeres and telomerase in genomic instability, senescence and cancer.
Deng Y, Chang S. Deng Y, et al. Lab Invest. 2007 Nov;87(11):1071-6. doi: 10.1038/labinvest.3700673. Epub 2007 Sep 3. Lab Invest. 2007. PMID: 17767195 Review.
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