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Role of the permeability transition pore complex in lethal inter-organelle crosstalk.
Sharaf El Dein O, Gallerne C, Deniaud A, Brenner C, Lemaire C. Sharaf El Dein O, et al. Front Biosci (Landmark Ed). 2009 Jan 1;14:3465-82. doi: 10.2741/3465. Front Biosci (Landmark Ed). 2009. PMID: 19273287 Review.
Activation of this self-protective pathway gives the cell a chance to restore normal ER function. In the case of prolonged or severe stress conditions, or if the ER dysfunctions cannot be compensated, apoptosis is ultimately activated to eliminate stressed cells. ...
Activation of this self-protective pathway gives the cell a chance to restore normal ER function. In the case of prolonged or severe …
Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis.
Deniaud A, Sharaf el dein O, Maillier E, Poncet D, Kroemer G, Lemaire C, Brenner C. Deniaud A, et al. Oncogene. 2008 Jan 10;27(3):285-99. doi: 10.1038/sj.onc.1210638. Epub 2007 Aug 13. Oncogene. 2008. PMID: 17700538
The specificity of this apoptosis pathway was validated in cells using a panel of pharmacological agents that chelate Ca2+ (BAPTA-AM) or inhibit inositol-1,4,5-trisphosphate receptor (IP(3)R; 2-aminoethoxydiphenyl borate), voltage-dependent anion channel (VDAC) (4,4'-diiso …
The specificity of this apoptosis pathway was validated in cells using a panel of pharmacological agents that chelate Ca2+ (BAPTA-AM) …
GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilization.
Tarze A, Deniaud A, Le Bras M, Maillier E, Molle D, Larochette N, Zamzami N, Jan G, Kroemer G, Brenner C. Tarze A, et al. Oncogene. 2007 Apr 19;26(18):2606-20. doi: 10.1038/sj.onc.1210074. Epub 2006 Oct 30. Oncogene. 2007. PMID: 17072346
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. ...The protein mediates a cyclosporin A-inhibitable permeability transition, characterized by a loss o …
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chro …
Mitochondrial membrane permeabilization by HIV-1 Vpr.
Deniaud A, Brenner C, Kroemer G. Deniaud A, et al. Mitochondrion. 2004 Jul;4(2-3):223-33. doi: 10.1016/j.mito.2004.06.012. Mitochondrion. 2004. PMID: 16120388
The mitochondrion is a privileged target for apoptosis-modulatory proteins of viral origin. Thus, viral protein R (Vpr) can target mitochondria and induce apoptosis via a specific interaction with the permeability transition pore complex (PTPC). ...The Vpr/ANT inter …
The mitochondrion is a privileged target for apoptosis-modulatory proteins of viral origin. Thus, viral protein R (Vpr) can target mi …
Chemosensitization by knockdown of adenine nucleotide translocase-2.
Le Bras M, Borgne-Sanchez A, Touat Z, El Dein OS, Deniaud A, Maillier E, Lecellier G, Rebouillat D, Lemaire C, Kroemer G, Jacotot E, Brenner C. Le Bras M, et al. Cancer Res. 2006 Sep 15;66(18):9143-52. doi: 10.1158/0008-5472.CAN-05-4407. Cancer Res. 2006. PMID: 16982757
Mitochondrial membrane permeabilization (MMP) is a rate-limiting step of apoptosis, including in anticancer chemotherapy. Adenine nucleotide translocase (ANT) mediates the exchange of ADP and ATP on the inner mitochondrial membrane in healthy cells. ...These data identify …
Mitochondrial membrane permeabilization (MMP) is a rate-limiting step of apoptosis, including in anticancer chemotherapy. Adenine nuc …
Peptido-targeting of the mitochondrial transition pore complex for therapeutic apoptosis induction.
Deniaud A, Hoebeke J, Briand JP, Muller S, Jacotot E, Brenner C. Deniaud A, et al. Curr Pharm Des. 2006;12(34):4501-11. doi: 10.2174/138161206779010530. Curr Pharm Des. 2006. PMID: 17168756 Review.
The permeability transition pore (PTPC), a polyprotein complex, participates in the mitochondrial homeostasis as well as in the mitochondrial phase of the intrinsic pathway of apoptosis. ...As a consequence, PTPC can act as a coordinator of the pro-apoptotic …
The permeability transition pore (PTPC), a polyprotein complex, participates in the mitochondrial homeostasis as well as in the mitoc …
Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis.
Sourdeval M, Lemaire C, Deniaud A, Taysse L, Daulon S, Breton P, Brenner C, Boisvieux-Ulrich E, Marano F. Sourdeval M, et al. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1. Apoptosis. 2006. PMID: 16738803
In the present study, the toxicity of yperite, SM, and its structural analogue mechlorethamine, HN2, was investigated in a human bronchial epithelial cell line 16HBE. ...Apoptosis, occurring only in detached cells, could be recognized as anoikis and the mitochondrion, invo …
In the present study, the toxicity of yperite, SM, and its structural analogue mechlorethamine, HN2, was investigated in a human bron …
Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis.
Verrier F, Deniaud A, Lebras M, Métivier D, Kroemer G, Mignotte B, Jan G, Brenner C. Verrier F, et al. Oncogene. 2004 Oct 21;23(49):8049-64. doi: 10.1038/sj.onc.1208001. Oncogene. 2004. PMID: 15377997
Bax, Bcl-2, subunits of the respiratory chain, a subunit of the phosphatase PP2A, phospholipase PLC beta 4 and IP3 receptor). ...Thus, ANT is connected to mitochondrial proteins as well as to proteins from other organelles such as the endoplasmic reticulum forming a
Bax, Bcl-2, subunits of the respiratory chain, a subunit of the phosphatase PP2A, phospholipase PLC beta 4 and IP3 receptor). ...Thus …
Voltage-dependent anion channel transports calcium ions through biomimetic membranes.
Deniaud A, Rossi C, Berquand A, Homand J, Campagna S, Knoll W, Brenner C, Chopineau J. Deniaud A, et al. Langmuir. 2007 Mar 27;23(7):3898-905. doi: 10.1021/la063105+. Epub 2007 Feb 22. Langmuir. 2007. PMID: 17315898
The mitochondrial outer membrane channel (VDAC), a central player in mitochondria and cell death, was reconstituted in polymer-supported phospholipid bilayers. ...The novel setup may allow the study of the assembly of a polyprotein complex centered on VDAC and its r …
The mitochondrial outer membrane channel (VDAC), a central player in mitochondria and cell death, was reconstituted in polymer-suppor …
Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor.
Weaver JG, Tarze A, Moffat TC, Lebras M, Deniaud A, Brenner C, Bren GD, Morin MY, Phenix BN, Dong L, Jiang SX, Sim VL, Zurakowski B, Lallier J, Hardin H, Wettstein P, van Heeswijk RP, Douen A, Kroemer RT, Hou ST, Bennett SA, Lynch DH, Kroemer G, Badley AD. Weaver JG, et al. J Clin Invest. 2005 Jul;115(7):1828-38. doi: 10.1172/JCI22954. J Clin Invest. 2005. PMID: 15937550 Free PMC article.
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