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The spleen assumes a major role in blood glucose regulation in type 1 diabetes patients treated with BCG.
Dias HF, Fu JF, Luck TG, Wolfe GE, Hostetter ER, Ng NC, Zheng H, Kühtreiber WM, Price JC, Catana C, Faustman DL. Dias HF, et al. Among authors: faustman dl. Sci Rep. 2024 Jul 30;14(1):17611. doi: 10.1038/s41598-024-67905-x. Sci Rep. 2024. PMID: 39080423 Free PMC article.
This effect appears to be driven by a BCG-induced shift in lymphoid cells' glucose metabolism from oxidative phosphorylation to aerobic glycolysis. ...We also injected BALB/c mice with BCG to test for the presence of BCG in various organs. Results from both s …
This effect appears to be driven by a BCG-induced shift in lymphoid cells' glucose metabolism from oxidative phosphorylation to aerob …
Late in the US pandemic, multi-dose BCG vaccines protect against COVID-19 and infectious diseases.
Kühtreiber WM, Hostetter ER, Wolfe GE, Vaishnaw MS, Goldstein R, Bulczynski ER, Hullavarad NS, Braley JE, Zheng H, Faustman DL. Kühtreiber WM, et al. Among authors: faustman dl. iScience. 2024 May 22;27(6):109881. doi: 10.1016/j.isci.2024.109881. eCollection 2024 Jun 21. iScience. 2024. PMID: 39055605 Free PMC article.
In contrast to the protection afforded by BCG, as reported by others, COVID-19 mRNA vaccine alone provided no protection from COVID-19 disease (p = 0.43). BCG vaccination efficacy was unaffected by concurrent COVID-19 vaccinations; COVID-19 vaccines neither helped n …
In contrast to the protection afforded by BCG, as reported by others, COVID-19 mRNA vaccine alone provided no protection from COVID-1 …
Association of BCG Vaccine Treatment With Death and Dementia in Patients With Non-Muscle-Invasive Bladder Cancer.
Weinberg MS, Zafar A, Magdamo C, Chung SY, Chou WH, Nayan M, Deodhar M, Frendl DM, Feldman AS, Faustman DL, Arnold SE, Vakulenko-Lagun B, Das S. Weinberg MS, et al. Among authors: faustman dl. JAMA Netw Open. 2023 May 1;6(5):e2314336. doi: 10.1001/jamanetworkopen.2023.14336. JAMA Netw Open. 2023. PMID: 37204792 Free PMC article.
IMPORTANCE: The BCG vaccine-used worldwide to prevent tuberculosis-confers multiple nonspecific beneficial effects, and intravesical BCG vaccine is currently the recommended treatment for non-muscle-invasive bladder cancer (NMIBC). ...Treatment with BCG vacci …
IMPORTANCE: The BCG vaccine-used worldwide to prevent tuberculosis-confers multiple nonspecific beneficial effects, and intravesical …
Bacille Calmette Guerin (BCG) and prevention of types 1 and 2 diabetes: Results of two observational studies.
Dias HF, Mochizuki Y, Kühtreiber WM, Takahashi H, Zheng H, Faustman DL. Dias HF, et al. Among authors: faustman dl. PLoS One. 2023 Jan 20;18(1):e0276423. doi: 10.1371/journal.pone.0276423. eCollection 2023. PLoS One. 2023. PMID: 36662841 Free PMC article.
An earlier clinical trial in type 1 diabetic subjects (T1Ds) found that repeat BCG vaccinations succeeded in lowering HbA1c values over a multi-year course. Here we seek to determine whether BCG therapy for bladder cancer may improve blood sugar levels in patients w …
An earlier clinical trial in type 1 diabetic subjects (T1Ds) found that repeat BCG vaccinations succeeded in lowering HbA1c values ov …
BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes.
Takahashi H, Kühtreiber WM, Keefe RC, Lee AH, Aristarkhova A, Dias HF, Ng N, Nelson KJ, Bien S, Scheffey D, Faustman DL. Takahashi H, et al. Among authors: faustman dl. Sci Adv. 2022 Nov 18;8(46):eabq7240. doi: 10.1126/sciadv.abq7240. Epub 2022 Nov 16. Sci Adv. 2022. PMID: 36383663 Free PMC article.
The BCG (Bacille Calmette-Guerin) vaccine, introduced 100 years ago for tuberculosis prevention, has emerging therapeutic off-target benefits for autoimmunity. In randomized controlled trials, BCG vaccinations were shown to gradually improve two autoimmune condition …
The BCG (Bacille Calmette-Guerin) vaccine, introduced 100 years ago for tuberculosis prevention, has emerging therapeutic off-target …
Multiple BCG vaccinations for the prevention of COVID-19 and other infectious diseases in type 1 diabetes.
Faustman DL, Lee A, Hostetter ER, Aristarkhova A, Ng NC, Shpilsky GF, Tran L, Wolfe G, Takahashi H, Dias HF, Braley J, Zheng H, Schoenfeld DA, Kühtreiber WM. Faustman DL, et al. Cell Rep Med. 2022 Sep 20;3(9):100728. doi: 10.1016/j.xcrm.2022.100728. Epub 2022 Aug 15. Cell Rep Med. 2022. PMID: 36027906 Free PMC article. Clinical Trial.
We enrolled 144 subjects and randomized 96 to BCG and 48 to placebo. There were no dropouts over the 15-month trial. A cumulative incidence of 12.5% of placebo-treated and 1% of BCG-treated participants meets criteria for confirmed COVID-19, yielding an efficacy of …
We enrolled 144 subjects and randomized 96 to BCG and 48 to placebo. There were no dropouts over the 15-month trial. A cumulative inc …
Off-target effects of bacillus Calmette-Guérin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19.
Messina NL, Germano S, McElroy R, Rudraraju R, Bonnici R, Pittet LF, Neeland MR, Nicholson S, Subbarao K, Curtis N; BRACE trial. Messina NL, et al. Clin Transl Immunology. 2022 Apr 22;11(4):e1387. doi: 10.1002/cti2.1387. eCollection 2022. Clin Transl Immunology. 2022. PMID: 35573165 Free PMC article.
Multiple epidemiological studies and randomised controlled trials (RCTs) are investigating the protective effect of BCG against coronavirus disease 2019 (COVID-19). Using samples from participants in a placebo-controlled RCT aiming to determine whether BCG vaccinati …
Multiple epidemiological studies and randomised controlled trials (RCTs) are investigating the protective effect of BCG against coron …
BCG vaccination to reduce the impact of COVID-19 in healthcare workers: Protocol for a randomised controlled trial (BRACE trial).
Pittet LF, Messina NL, Gardiner K, Orsini F, Abruzzo V, Bannister S, Bonten M, Campbell JL, Croda J, Dalcolmo M, Elia S, Germano S, Goodall C, Gwee A, Jamieson T, Jardim B, Kollmann TR, Guimarães Lacerda MV, Lee KJ, Legge D, Lucas M, Lynn DJ, McDonald E, Manning L, Munns CF, Perrett KP, Prat Aymerich C, Richmond P, Shann F, Sudbury E, Villanueva P, Wood NJ, Lieschke K, Subbarao K, Davidson A, Curtis N; BRACE trial Consortium Group. Pittet LF, et al. BMJ Open. 2021 Oct 28;11(10):e052101. doi: 10.1136/bmjopen-2021-052101. BMJ Open. 2021. PMID: 34711598 Free PMC article.
METHODS AND ANALYSIS: This international multicentre phase III randomised controlled trial aims to determine if BCG vaccination reduces the incidence of symptomatic and severe COVID-19 at 6 months (co-primary outcomes) compared with no BCG vaccination. We plan to ra …
METHODS AND ANALYSIS: This international multicentre phase III randomised controlled trial aims to determine if BCG vaccination reduc …
20 results