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Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer.
Denmeade SR, Lin XS, Isaacs JT. Denmeade SR, et al. Prostate. 1996 Apr;28(4):251-65. doi: 10.1002/(SICI)1097-0045(199604)28:4<251::AID-PROS6>3.0.CO;2-G. Prostate. 1996. PMID: 8602401 Review.
Prognostic factors for clinical outcomes in patients with metastatic castration resistant prostate cancer treated with sequential novel androgen receptor-directed therapies.
Nadal R, Tsai HL, Sinibaldi VJ, Paller CJ, Antonarakis ES, Denmeade SR, Carducci MA, Eisenberger MA. Nadal R, et al. Among authors: denmeade sr. Prostate. 2016 Apr;76(5):512-20. doi: 10.1002/pros.23141. Epub 2015 Dec 22. Prostate. 2016. PMID: 26689606
Thapsigargin analogues for targeting programmed death of androgen-independent prostate cancer cells.
Christensen SB, Andersen A, Kromann H, Treiman M, Tombal B, Denmeade S, Isaacs JT. Christensen SB, et al. Among authors: denmeade s. Bioorg Med Chem. 1999 Jul;7(7):1273-80. doi: 10.1016/s0968-0896(99)00074-7. Bioorg Med Chem. 1999. PMID: 10465403
The effect of the frequency and duration of PSA measurement on PSA doubling time calculations in men with biochemically recurrent prostate cancer.
Paller CJ, Olatoye D, Xie S, Zhou X, Denmeade SR, Eisenberger MA, Antonarakis ES, Carducci MA, Rosner GL. Paller CJ, et al. Among authors: denmeade sr. Prostate Cancer Prostatic Dis. 2014 Mar;17(1):28-33. doi: 10.1038/pcan.2013.40. Epub 2013 Oct 8. Prostate Cancer Prostatic Dis. 2014. PMID: 24100642 Free PMC article.
Pan-trk inhibition decreases metastasis and enhances host survival in experimental models as a result of its selective induction of apoptosis of prostate cancer cells.
Weeraratna AT, Dalrymple SL, Lamb JC, Denmeade SR, Miknyoczki S, Dionne CA, Isaacs JT. Weeraratna AT, et al. Among authors: denmeade sr. Clin Cancer Res. 2001 Aug;7(8):2237-45. Clin Cancer Res. 2001. PMID: 11489797
A supramicromolar elevation of intracellular free calcium ([Ca(2+)](i)) is consistently required to induce the execution phase of apoptosis.
Tombal B, Denmeade SR, Gillis JM, Isaacs JT. Tombal B, et al. Among authors: denmeade sr. Cell Death Differ. 2002 May;9(5):561-73. doi: 10.1038/sj.cdd.4400999. Cell Death Differ. 2002. PMID: 11973614
In vivo activity of a PSA-activated doxorubicin prodrug against PSA-producing human prostate cancer xenografts.
Khan SR, Denmeade SR. Khan SR, et al. Among authors: denmeade sr. Prostate. 2000 Sep 15;45(1):80-3. doi: 10.1002/1097-0045(20000915)45:1<80::aid-pros10>3.0.co;2-q. Prostate. 2000. PMID: 10960846
Delayed micromolar elevation in intracellular calcium precedes induction of apoptosis in thapsigargin-treated breast cancer cells.
Jackisch C, Hahm HA, Tombal B, McCloskey D, Butash K, Davidson NE, Denmeade SR. Jackisch C, et al. Among authors: denmeade sr. Clin Cancer Res. 2000 Jul;6(7):2844-50. Clin Cancer Res. 2000. PMID: 10914733
Programmed Cell Death (Apoptosis) and Cancer Chemotherapy.
Denmeade SR, Isaacs JT. Denmeade SR, et al. Cancer Control. 1996 Jul;3(4):303-309. doi: 10.1177/107327489600300401. Cancer Control. 1996. PMID: 10765221
Inhibition of caspase activity does not prevent the signaling phase of apoptosis in prostate cancer cells.
Denmeade SR, Lin XS, Tombal B, Isaacs JT. Denmeade SR, et al. Prostate. 1999 Jun 1;39(4):269-79. doi: 10.1002/(sici)1097-0045(19990601)39:4<269::aid-pros7>3.0.co;2-f. Prostate. 1999. PMID: 10344216
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