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Page 1
Signaling in the innate immune response.
Kim DH, Ewbank JJ. Kim DH, et al. WormBook. 2018 Aug 14;2018:1-35. doi: 10.1895/wormbook.1.83.2. WormBook. 2018. PMID: 26694508 Free PMC article. Review.
The nematode Caenorhabditis elegans relies on its innate immune defenses to counter infection. ...We discuss what is known of the activation of innate immunity in C. elegans, via pathogen recognition or sensing the damage provoked by infection. ...
The nematode Caenorhabditis elegans relies on its innate immune defenses to counter infection. ...We discuss what is known of the act …
Host-microbe interactions and the behavior of Caenorhabditis elegans.
Kim DH, Flavell SW. Kim DH, et al. J Neurogenet. 2020 Sep-Dec;34(3-4):500-509. doi: 10.1080/01677063.2020.1802724. Epub 2020 Aug 12. J Neurogenet. 2020. PMID: 32781873 Free PMC article. Review.
Microbes are ubiquitous in the natural environment of Caenorhabditis elegans. Bacteria serve as a food source for C. elegans but may also cause infection in the nematode host. The sensory nervous system of C. elegans detects diverse microbial molecules, rangi …
Microbes are ubiquitous in the natural environment of Caenorhabditis elegans. Bacteria serve as a food source for C. elegans b …
Bacteria and the aging and longevity of Caenorhabditis elegans.
Kim DH. Kim DH. Annu Rev Genet. 2013;47:233-46. doi: 10.1146/annurev-genet-111212-133352. Annu Rev Genet. 2013. PMID: 24274752 Review.
The molecular genetic analysis of longevity of Caenorhabditis elegans has yielded fundamental insights into evolutionarily conserved pathways and processes governing the physiology of aging. Recent studies suggest that interactions between C. elegans and its microbi …
The molecular genetic analysis of longevity of Caenorhabditis elegans has yielded fundamental insights into evolutionarily conserved …
Behavioral avoidance of pathogenic bacteria by Caenorhabditis elegans.
Meisel JD, Kim DH. Meisel JD, et al. Among authors: kim dh. Trends Immunol. 2014 Oct;35(10):465-70. doi: 10.1016/j.it.2014.08.008. Epub 2014 Sep 15. Trends Immunol. 2014. PMID: 25240986 Review.
The simple animal host Caenorhabditis elegans utilizes its nervous system to respond to diverse microbial cues, and can engage in a protective behavioral avoidance response to environmental pathogens. ...We review here these findings and discuss how the microbial cues and …
The simple animal host Caenorhabditis elegans utilizes its nervous system to respond to diverse microbial cues, and can engage in a p …
Transcriptional responses to pathogens in Caenorhabditis elegans.
Shivers RP, Youngman MJ, Kim DH. Shivers RP, et al. Among authors: kim dh. Curr Opin Microbiol. 2008 Jun;11(3):251-6. doi: 10.1016/j.mib.2008.05.014. Epub 2008 Jun 21. Curr Opin Microbiol. 2008. PMID: 18567532 Free PMC article. Review.
Evolutionarily conserved signaling pathways, such as the p38 and ERK MAPK pathways, the TGF-beta pathway, and the insulin-signaling pathway are required for resistance to pathogens in Caenorhabditis elegans. Recent microarray expression profiling studies have identified bo …
Evolutionarily conserved signaling pathways, such as the p38 and ERK MAPK pathways, the TGF-beta pathway, and the insulin-signaling pathway …
Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans.
Kim DH, Ausubel FM. Kim DH, et al. Curr Opin Immunol. 2005 Feb;17(1):4-10. doi: 10.1016/j.coi.2004.11.007. Curr Opin Immunol. 2005. PMID: 15653303 Review.
Genetic and functional genomic approaches have begun to define the molecular determinants of pathogen resistance in Caenorhabditis elegans. Conserved signal transduction components are required for pathogen resistance, including a Toll/IL-1 receptor domain adaptor protein …
Genetic and functional genomic approaches have begun to define the molecular determinants of pathogen resistance in Caenorhabditis elegan …
Neuronal KGB-1 JNK MAPK signaling regulates the dauer developmental decision in response to environmental stress in Caenorhabditis elegans.
Dogra D, Kulalert W, Schroeder FC, Kim DH. Dogra D, et al. Among authors: kim dh. Genetics. 2022 Jan 4;220(1):iyab186. doi: 10.1093/genetics/iyab186. Genetics. 2022. PMID: 34726729 Free PMC article.
In response to stressful growth conditions of high population density, food scarcity, and elevated temperature, young larvae of nematode Caenorhabditis elegans can enter a developmentally arrested stage called dauer that is characterized by dramatic anatomic and metabolic …
In response to stressful growth conditions of high population density, food scarcity, and elevated temperature, young larvae of nematode Cae …
A decline in p38 MAPK signaling underlies immunosenescence in Caenorhabditis elegans.
Youngman MJ, Rogers ZN, Kim DH. Youngman MJ, et al. Among authors: kim dh. PLoS Genet. 2011 May;7(5):e1002082. doi: 10.1371/journal.pgen.1002082. Epub 2011 May 19. PLoS Genet. 2011. PMID: 21625567 Free PMC article.
Here we show that C. elegans exhibits increased susceptibility to bacterial infection with age, and we establish that aging is associated with a decline in the activity of the conserved PMK-1 p38 mitogen-activated protein kinase pathway, which regulates innate immunity in …
Here we show that C. elegans exhibits increased susceptibility to bacterial infection with age, and we establish that aging is associ …
PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans.
Hilbert ZA, Kim DH. Hilbert ZA, et al. Among authors: kim dh. Elife. 2018 Jul 19;7:e36547. doi: 10.7554/eLife.36547. Elife. 2018. PMID: 30024377 Free PMC article.
Building on our previous work which described the sexually dimorphic expression of a neuroendocrine ligand, DAF-7, and its role in behavioral decision-making in C. elegans (Hilbert and Kim, 2017), we show here that sex-specific expression of daf-7 is regulated by another n …
Building on our previous work which described the sexually dimorphic expression of a neuroendocrine ligand, DAF-7, and its role in behaviora …
Caenorhabditis elegans NPR-1-mediated behaviors are suppressed in the presence of mucoid bacteria.
Reddy KC, Hunter RC, Bhatla N, Newman DK, Kim DH. Reddy KC, et al. Among authors: kim dh. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12887-92. doi: 10.1073/pnas.1108265108. Epub 2011 Jul 18. Proc Natl Acad Sci U S A. 2011. PMID: 21768378 Free PMC article.
Caenorhabditis elegans exhibits a diverse range of behaviors in response to bacteria. ...Alginate biosynthesis by laboratory and clinical isolates of mucoid P. aeruginosa is necessary and sufficient to attenuate NPR-1-mediated behavior and it suppresses C. elegans p …
Caenorhabditis elegans exhibits a diverse range of behaviors in response to bacteria. ...Alginate biosynthesis by laboratory and clin …
38 results