Denny WA - Search Results

1

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel.

Sutherland HS, Tong AST, Choi PJ, Blaser A, Conole D, Franzblau SG, Lotlikar MU, Cooper CB, Upton AM, Denny WA, Palmer BD. Sutherland HS, et al. Among authors: denny wa. Bioorg Med Chem. 2019 Apr 1;27(7):1292-1307. doi: 10.1016/j.bmc.2019.02.026. Epub 2019 Feb 15. Bioorg Med Chem. 2019. PMID: 30803745 Free PMC article.

2

Synthesis, reduction potentials, and antitubercular activity of ring A/B analogues of the bioreductive drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

Thompson AM, Blaser A, Anderson RF, Shinde SS, Franzblau SG, Ma Z, Denny WA, Palmer BD. Thompson AM, et al. Among authors: denny wa. J Med Chem. 2009 Feb 12;52(3):637-45. doi: 10.1021/jm801087e. J Med Chem. 2009. PMID: 19099398

3

Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

Palmer BD, Thompson AM, Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. Palmer BD, et al. Among authors: denny wa. J Med Chem. 2010 Jan 14;53(1):282-94. doi: 10.1021/jm901207n. J Med Chem. 2010. PMID: 19928920

4

Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains.

Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Palmer BD, Denny WA, Thompson AM. Sutherland HS, et al. Among authors: denny wa. J Med Chem. 2010 Jan 28;53(2):855-66. doi: 10.1021/jm901378u. J Med Chem. 2010. PMID: 19968290

5

Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

Kmentova I, Sutherland HS, Palmer BD, Blaser A, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA, Thompson AM. Kmentova I, et al. Among authors: denny wa. J Med Chem. 2010 Dec 9;53(23):8421-39. doi: 10.1021/jm101288t. Epub 2010 Nov 11. J Med Chem. 2010. PMID: 21069962

6

The nitroimidazooxazines (PA-824 and analogs): structure-activity relationship and mechanistic studies.

Denny WA, Palmer BD. Denny WA, et al. Future Med Chem. 2010 Aug;2(8):1295-304. doi: 10.4155/fmc.10.207. Future Med Chem. 2010. PMID: 21426020 Review.

7

Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5h-imidazo[2,1-b][1,3]oxazine (PA-824).

Thompson AM, Sutherland HS, Palmer BD, Kmentova I, Blaser A, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. Thompson AM, et al. Among authors: denny wa. J Med Chem. 2011 Oct 13;54(19):6563-85. doi: 10.1021/jm200377r. Epub 2011 Sep 1. J Med Chem. 2011. PMID: 21846109

8

Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

Blaser A, Palmer BD, Sutherland HS, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Thompson AM, Denny WA. Blaser A, et al. Among authors: denny wa. J Med Chem. 2012 Jan 12;55(1):312-26. doi: 10.1021/jm2012276. Epub 2011 Dec 29. J Med Chem. 2012. PMID: 22148391

9

Synthesis and structure-activity relationships for extended side chain analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

Palmer BD, Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA, Thompson AM. Palmer BD, et al. Among authors: denny wa. J Med Chem. 2015 Apr 9;58(7):3036-59. doi: 10.1021/jm501608q. Epub 2015 Mar 27. J Med Chem. 2015. PMID: 25781074

10

Biarylmethoxy 2-nitroimidazooxazine antituberculosis agents: Effects of proximal ring substitution and linker reversal on metabolism and efficacy.

Thompson AM, Blaser A, Palmer BD, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. Thompson AM, et al. Among authors: denny wa. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3804-9. doi: 10.1016/j.bmcl.2015.07.084. Epub 2015 Jul 28. Bioorg Med Chem Lett. 2015. PMID: 26253632

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