Denton TT - Search Results

1

Nicotine-related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6.

Denton TT, Zhang X, Cashman JR. Denton TT, et al. Biochem Pharmacol. 2004 Feb 15;67(4):751-6. doi: 10.1016/j.bcp.2003.10.022. Biochem Pharmacol. 2004. PMID: 14757175

2

Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.

Yano JK, Denton TT, Cerny MA, Zhang X, Johnson EF, Cashman JR. Yano JK, et al. Among authors: denton tt. J Med Chem. 2006 Nov 30;49(24):6987-7001. doi: 10.1021/jm060519r. J Med Chem. 2006. PMID: 17125252

3

5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6.

Denton TT, Zhang X, Cashman JR. Denton TT, et al. J Med Chem. 2005 Jan 13;48(1):224-39. doi: 10.1021/jm049696n. J Med Chem. 2005. PMID: 15634016

4

Identification of the 4-Position of 3-Alkynyl and 3-Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P-450 2A6 Inhibition.

Denton TT, Srivastava P, Xia Z, Chen G, Watson CJW, Wynd A, Lazarus P. Denton TT, et al. J Med Chem. 2018 Aug 23;61(16):7065-7086. doi: 10.1021/acs.jmedchem.8b00084. Epub 2018 Aug 1. J Med Chem. 2018. PMID: 29995408 Free PMC article.

5

Multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters.

Shen D, Hensley K, Denton TT. Shen D, et al. Among authors: denton tt. Bioorg Med Chem Lett. 2018 Feb 15;28(4):562-565. doi: 10.1016/j.bmcl.2018.01.052. Epub 2018 Feb 1. Bioorg Med Chem Lett. 2018. PMID: 29398540 Free PMC article.

6

Synthesis and preliminary evaluation of trans-3,4-conformationally-restricted glutamate and pyroglutamate analogues as novel EAAT2 inhibitors.

Denton T, Seib T, Bridges R, Thompson C. Denton T, et al. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3209-13. doi: 10.1016/s0960-894x(02)00520-6. Bioorg Med Chem Lett. 2002. PMID: 12372536

7

Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement.

Hensley K, Denton TT. Hensley K, et al. Among authors: denton tt. Free Radic Biol Med. 2015 Jan;78:123-34. doi: 10.1016/j.freeradbiomed.2014.10.581. Epub 2014 Nov 6. Free Radic Biol Med. 2015. PMID: 25463282 Free PMC article. Review.

8

Preparation of N-alkylbis(3-aminopropyl)amines by the catalytic hydrogenation of N-alkylbis(cyanoethyl)amines.

Denton TT, Joyce AS, Kiely DE. Denton TT, et al. J Org Chem. 2007 Jun 22;72(13):4997-5000. doi: 10.1021/jo070245v. Epub 2007 May 31. J Org Chem. 2007. PMID: 17536864

9

Analysis of conformationally restricted alpha-ketoglutarate analogues as substrates of dehydrogenases and aminotransferases.

Denton TT, Thompson CM, Cooper AJ. Denton TT, et al. Anal Biochem. 2001 Nov 15;298(2):265-74. doi: 10.1006/abio.2001.5366. Anal Biochem. 2001. PMID: 11700982

10

Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease.

Banerjee K, Munshi S, Xu H, Frank DE, Chen HL, Chu CT, Yang J, Cho S, Kagan VE, Denton TT, Tyurina YY, Jiang JF, Gibson GE. Banerjee K, et al. Among authors: denton tt. Neurochem Int. 2016 Jun;96:32-45. doi: 10.1016/j.neuint.2016.02.011. Epub 2016 Feb 23. Neurochem Int. 2016. PMID: 26923918 Free PMC article.

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