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2013 2
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2016 3
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2019 3
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Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum.
Piao X, Yamazaki S, Komazawa-Sakon S, Miyake S, Nakabayashi O, Kurosawa T, Mikami T, Tanaka M, Van Rooijen N, Ohmuraya M, Oikawa A, Kojima Y, Kakuta S, Uchiyama Y, Tanaka M, Nakano H. Piao X, et al. Hepatology. 2017 Jan;65(1):237-252. doi: 10.1002/hep.28878. Epub 2016 Nov 25. Hepatology. 2017. PMID: 27770461
Depletion of Kupffer cells (KCs) by clodronate liposomes did not impair clearance of dying hepatocytes or exacerbate hepatitis in Cflar(Hep-low) mice. To elucidate the roles of BM-derived monocytes and neutrophils in clearance of apoptotic hepatocytes,
Depletion of Kupffer cells (KCs) by clodronate liposomes did not impair clearance of dying hepatocytes or exacerbate
Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis.
Farooq M, Filliol A, Simoes Eugénio M, Piquet-Pellorce C, Dion S, Raguenes-Nicol C, Jan A, Dimanche-Boitrel MT, Le Seyec J, Samson M. Farooq M, et al. Cell Death Dis. 2019 Jan 8;10(1):12. doi: 10.1038/s41419-018-1277-3. Cell Death Dis. 2019. PMID: 30622241 Free PMC article.
Mice deficient for RIPK1, specifically in liver parenchymal cells (Ripk1(LPC-KO)) and their wild-type littermates (Ripk1(fl/fl)), were challenged by either the murine hepatitis virus type 3 (MHV3) or poly I:C, a synthetic analog of double-stranded RNA mimicking vira …
Mice deficient for RIPK1, specifically in liver parenchymal cells (Ripk1(LPC-KO)) and their wild-type littermates (Ripk1(fl/fl)), wer …
RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis.
Filliol A, Piquet-Pellorce C, Raguénès-Nicol C, Dion S, Farooq M, Lucas-Clerc C, Vandenabeele P, Bertrand MJM, Le Seyec J, Samson M. Filliol A, et al. J Hepatol. 2017 Jun;66(6):1205-1213. doi: 10.1016/j.jhep.2017.01.005. Epub 2017 Jan 11. J Hepatol. 2017. PMID: 28088582 Free article.
BACKGROUND & AIMS: The severity of liver diseases is exacerbated by the death of hepatocytes, which can be induced by the sensing of pathogen associated molecular patterns (PAMPs) derived from the gut microbiota. ...METHODS: Hepatitis was induced i …
BACKGROUND & AIMS: The severity of liver diseases is exacerbated by the death of hepatocytes, which can be induced by the …
Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use.
Bukong TN, Cho Y, Iracheta-Vellve A, Saha B, Lowe P, Adejumo A, Furi I, Ambade A, Gyongyosi B, Catalano D, Kodys K, Szabo G. Bukong TN, et al. J Hepatol. 2018 Nov;69(5):1145-1154. doi: 10.1016/j.jhep.2018.07.005. Epub 2018 Jul 18. J Hepatol. 2018. PMID: 30030149 Free PMC article.
In vivo, anti-Ly6G antibody (IA8) was used for neutrophil depletion. RESULTS: Inducers of NETs (endotoxin and bacterial DNA) significantly increased in the circulation after binge alcohol drinking in humans. ...Finally, depletion of neutrophils prior to binge …
In vivo, anti-Ly6G antibody (IA8) was used for neutrophil depletion. RESULTS: Inducers of NETs (endotoxin and bacterial DNA) s …
Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35.
Koda Y, Nakamoto N, Chu PS, Ugamura A, Mikami Y, Teratani T, Tsujikawa H, Shiba S, Taniki N, Sujino T, Miyamoto K, Suzuki T, Yamaguchi A, Morikawa R, Sato K, Sakamoto M, Yoshimoto T, Kanai T. Koda Y, et al. J Clin Invest. 2019 Jul 2;129(8):3201-3213. doi: 10.1172/JCI125863. eCollection 2019 Jul 2. J Clin Invest. 2019. PMID: 31264967 Free PMC article.
Selective depletion of pDCs in Siglechdtr/+ mice exacerbated concanavalin A-induced acute liver injury. In contrast, adoptively transferred BM-derived pDCs preferentially accumulated in the inflamed liver and protected against liver injury. ...However, the pr …
Selective depletion of pDCs in Siglechdtr/+ mice exacerbated concanavalin A-induced acute liver injury. In contrast, ad …
Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis.
Carrière V, Arshad MI, Le Seyec J, Lefevre B, Farooq M, Jan A, Manuel C, Touami-Bernard L, Lucas-Clerc C, Genet V, Gascan H, Girard JP, Chalmel F, Lamontagne L, Piquet-Pellorce C, Samson M. Carrière V, et al. Mediators Inflamm. 2017;2017:1359064. doi: 10.1155/2017/1359064. Epub 2017 May 4. Mediators Inflamm. 2017. PMID: 28607531 Free PMC article.
An increased depletion of B and T lymphocytes, NKT cells, dendritic cells, and macrophages was observed 48 h postinfection (PI) in IL-33 KO mice than that in WT mice. ...However, the IFNγ was strongly induced in WT mice with less profound expression in …
An increased depletion of B and T lymphocytes, NKT cells, dendritic cells, and macrophages was observed 48 h postinfect …
Roles of platelets and macrophages in the protective effects of lipopolysaccharide against concanavalin A-induced murine hepatitis.
Yu Z, Otsuka H, Yamaguchi K, Kuroishi T, Sasano T, Sugawara S, Nakamura M, Endo Y. Yu Z, et al. Biochim Biophys Acta. 2011 Sep;1812(9):1069-79. doi: 10.1016/j.bbadis.2011.06.005. Epub 2011 Jun 23. Biochim Biophys Acta. 2011. PMID: 21722729 Free article.
Against expectations, platelet-depletion significantly exacerbated ConA-hepatitis, and anti-P-selectin antibody and P-selectin receptor blockade reduced both ConA-induced HPA and hepatitis. ...In platelet-depleted mice, LPS-pretreatment s …
Against expectations, platelet-depletion significantly exacerbated ConA-hepatitis, and anti-P-selectin antibody and P-s …
Invariant NKT cell activation induces neutrophil accumulation and hepatitis: opposite regulation by IL-4 and IFN-γ.
Wang H, Feng D, Park O, Yin S, Gao B. Wang H, et al. Hepatology. 2013 Oct;58(4):1474-85. doi: 10.1002/hep.26471. Epub 2013 Aug 6. Hepatology. 2013. PMID: 23686838 Free PMC article.
Moreover, depletion of neutrophils eradicated α-Galcer-induced liver injury in wild-type, STAT1 knockout, and IFN-γ knockout mice. CONCLUSION: Our results propose a model in which activated iNKT cells rapidly release IL-4, which promotes neutrophil survival a …
Moreover, depletion of neutrophils eradicated α-Galcer-induced liver injury in wild-type, STAT1 knockout, and IFN-γ knockout m …
Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice.
Nakashima H, Nakashima M, Kinoshita M, Ikarashi M, Miyazaki H, Hanaka H, Imaki J, Seki S. Nakashima H, et al. Sci Rep. 2016 Oct 6;6:34466. doi: 10.1038/srep34466. Sci Rep. 2016. PMID: 27708340 Free PMC article.
We have recently reported that Kupffer cells consist of two subsets, radio-resistant resident CD68+ Kupffer cells and radio-sensitive recruited CD11b+ Kupffer cells/macrophages (Mφs). ...However, depletion of the resident subset by clodronate liposome …
We have recently reported that Kupffer cells consist of two subsets, radio-resistant resident CD68+ Kupffer cells and radio-se …
Opposing effects of prednisolone treatment on T/NKT cell- and hepatotoxin-mediated hepatitis in mice.
Kwon HJ, Won YS, Park O, Feng D, Gao B. Kwon HJ, et al. Hepatology. 2014 Mar;59(3):1094-106. doi: 10.1002/hep.26748. Epub 2014 Jan 21. Hepatology. 2014. PMID: 24115096 Free PMC article.
Prednisolone administration attenuated ConA- and α-GalCer-induced hepatitis and systemic inflammatory responses. Treating mice with prednisolone also suppressed inflammatory responses in a model of hepatotoxin (CCl4 )-induced hepatitis, but surprisingl …
Prednisolone administration attenuated ConA- and α-GalCer-induced hepatitis and systemic inflammatory responses. Treating mice …
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