Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35.
Koda Y, Nakamoto N, Chu PS, Ugamura A, Mikami Y, Teratani T, Tsujikawa H, Shiba S, Taniki N, Sujino T, Miyamoto K, Suzuki T, Yamaguchi A, Morikawa R, Sato K, Sakamoto M, Yoshimoto T, Kanai T.
Koda Y, et al.
J Clin Invest. 2019 Jul 2;129(8):3201-3213. doi: 10.1172/JCI125863. eCollection 2019 Jul 2.
J Clin Invest. 2019.
PMID: 31264967
Free PMC article.
Here, we show that the number of peripheral and hepatic plasmacytoid DCs (pDCs) decrease during acute liver injury in both humans and mice. Selective depletion of pDCs in Siglechdtr/+ mice exacerbated concanavalin A-induced acute liver injury. ...However, the …
Here, we show that the number of peripheral and hepatic plasmacytoid DCs (pDCs) decrease during acute liver injury in both humans and mice. …