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The blood-brain barrier in multiple sclerosis: microRNAs as key regulators.
Kamphuis WW, Derada Troletti C, Reijerkerk A, Romero IA, de Vries HE. Kamphuis WW, et al. Among authors: derada troletti c. CNS Neurol Disord Drug Targets. 2015;14(2):157-67. doi: 10.2174/1871527314666150116125246. CNS Neurol Disord Drug Targets. 2015. PMID: 25613507 Review.
Brain endothelial cell expression of SPARCL-1 is specific to chronic multiple sclerosis lesions and is regulated by inflammatory mediators in vitro.
Bridel C, Koel-Simmelink MJA, Peferoen L, Derada Troletti C, Durieux S, Gorter R, Nutma E, Gami P, Iacobaeus E, Brundin L, Kuhle J, Vrenken H, Killestein J, Piersma SR, Pham TV, De Vries HE, Amor S, Jimenez CR, Teunissen CE. Bridel C, et al. Among authors: derada troletti c. Neuropathol Appl Neurobiol. 2018 Jun;44(4):404-416. doi: 10.1111/nan.12412. Epub 2017 Jun 28. Neuropathol Appl Neurobiol. 2018. PMID: 28543098
Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology.
Derada Troletti C, Fontijn RD, Gowing E, Charabati M, van Het Hof B, Didouh I, van der Pol SMA, Geerts D, Prat A, van Horssen J, Kooij G, de Vries HE. Derada Troletti C, et al. Cell Death Dis. 2019 Jan 18;10(2):45. doi: 10.1038/s41419-018-1294-2. Cell Death Dis. 2019. PMID: 30718504 Free PMC article.
Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction.
Kooij G, Troletti CD, Leuti A, Norris PC, Riley I, Albanese M, Ruggieri S, Libreros S, van der Pol SMA, van Het Hof B, Schell Y, Guerrera G, Buttari F, Mercuri NB, Centonze D, Gasperini C, Battistini L, de Vries HE, Serhan CN, Chiurchiù V. Kooij G, et al. Among authors: troletti cd. Haematologica. 2020 Aug;105(8):2056-2070. doi: 10.3324/haematol.2019.219519. Epub 2019 Nov 28. Haematologica. 2020. PMID: 31780628 Free PMC article.
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ, Collins JJ, Wolozin B. Dusonchet J, et al. Among authors: derada troletti c. Hum Mol Genet. 2014 Sep 15;23(18):4887-905. doi: 10.1093/hmg/ddu202. Epub 2014 May 2. Hum Mol Genet. 2014. PMID: 24794857 Free PMC article.
Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome.
Derada Troletti C, Enzmann G, Chiurchiù V, Kamermans A, Tietz SM, Norris PC, Jahromi NH, Leuti A, van der Pol SMA, Schouten M, Serhan CN, de Vries HE, Engelhardt B, Kooij G. Derada Troletti C, et al. Cell Rep. 2021 Jun 1;35(9):109201. doi: 10.1016/j.celrep.2021.109201. Cell Rep. 2021. PMID: 34077725 Free PMC article.