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586 results

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Page 1
Dermorphin tetrapeptide analogs as potent and long-lasting analgesics with pharmacological profiles distinct from morphine.
Mizoguchi H, Bagetta G, Sakurada T, Sakurada S. Mizoguchi H, et al. Peptides. 2011 Feb;32(2):421-7. doi: 10.1016/j.peptides.2010.11.013. Epub 2010 Nov 30. Peptides. 2011. PMID: 21126548 Review.
Dermorphin (Tyr-d-Ala-Phe-Gly-Tyr-Pro-Ser-NH(2)) is a heptapeptide isolated from amphibian skin. With a very high affinity and selectivity for mu-opioid receptors, dermorphin shows an extremely potent antinociceptive effect. The structure-activity relationship studi …
Dermorphin (Tyr-d-Ala-Phe-Gly-Tyr-Pro-Ser-NH(2)) is a heptapeptide isolated from amphibian skin. With a very high affinity and select …
The dermorphin peptide family.
Melchiorri P, Negri L. Melchiorri P, et al. Gen Pharmacol. 1996 Oct;27(7):1099-107. doi: 10.1016/0306-3623(95)02149-3. Gen Pharmacol. 1996. PMID: 8981054 Review.
Dermorphin peptides are potent analgesics in rodents and primates, including man. Some dermorphins can enter the blood-brain barrier and produce central antinociception after peripheral administration. 3. The dermorphin family also includes mu 1-opioid recept …
Dermorphin peptides are potent analgesics in rodents and primates, including man. Some dermorphins can enter the blood-brain b …
Dermorphin [D-Arg2, Lys4] (1-4) Amide Attenuates Burn Pain by Inhibiting TRPV1/NR2B Mediated Neuroinflammatory Signalling.
Modi A, Uniyal A, Akhilesh, Tiwari V, Chouhan D, Agrawal S, Ummadisetty O, Tiwari V. Modi A, et al. Mol Neurobiol. 2025 Oct;62(10):12668-12687. doi: 10.1007/s12035-025-05068-0. Epub 2025 May 29. Mol Neurobiol. 2025. PMID: 40442534
This study aims to investigate the effects of Dermorphin [D-Arg2, Lys4] (1-4) amide (DALDA), a peripherally acting mu-opioid receptor (MOR) agonist in an animal model of burn injury-induced chronic pain while unravelling the underlying mechanisms. ...
This study aims to investigate the effects of Dermorphin [D-Arg2, Lys4] (1-4) amide (DALDA), a peripherally acting mu-opioid receptor …
Rediscovery of old drugs: the forgotten case of dermorphin for postoperative pain and palliation.
Hesselink JMK, Schatman ME. Hesselink JMK, et al. J Pain Res. 2018 Nov 23;11:2991-2995. doi: 10.2147/JPR.S186082. eCollection 2018. J Pain Res. 2018. PMID: 30538538 Free PMC article. Review.
This analysis makes a case for re-exploration of dermorphin for intrathecal use in postoperative pain and in a palliative context, with the goal of re-establishing this compound. Dermorphin was isolated from the skin of an Amazonian frog, characterized and identifie …
This analysis makes a case for re-exploration of dermorphin for intrathecal use in postoperative pain and in a palliative context, wi …
[Dermorphin: synthesis of analogs and structuro-functional relations].
Korshunova GA, Sumbatian NV. Korshunova GA, et al. Bioorg Khim. 1989 Jul;15(7):869-903. Bioorg Khim. 1989. PMID: 2684167 Review. Russian.
The review analyzes structure-activity relations among dermorphin analogues. Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) is one of natural opioid peptides having a unique structure and exerting a very potent and prolonged antinociceptive effect. Methods of der …
The review analyzes structure-activity relations among dermorphin analogues. Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) is …
Dermorphin [D-Arg2, Lys4] (1-4) Amide Alleviates Frostbite-Induced Pain by Regulating TRP Channel-Mediated Microglial Activation and Neuroinflammation.
Ummadisetty O, Akhilesh, Gadepalli A, Chouhan D, Patil U, Singh SP, Singh S, Tiwari V. Ummadisetty O, et al. Mol Neurobiol. 2024 Aug;61(8):6089-6100. doi: 10.1007/s12035-024-03949-4. Epub 2024 Jan 26. Mol Neurobiol. 2024. PMID: 38277118
In this study, we investigated the effect of dermorphin [D-Arg2, Lys4] (1-4) amide (DALDA), a peripheral mu-opioid receptor agonist, on frostbite injury and hypersensitivity induced by deep freeze magnet exposure in rats. ...
In this study, we investigated the effect of dermorphin [D-Arg2, Lys4] (1-4) amide (DALDA), a peripheral mu-opioid receptor agonist, …
Dermorphin blocks apneic response to intravenous bolus injection of fentanyl.
Zhuang J, Gao X, Shi S, Xu F. Zhuang J, et al. Toxicol Appl Pharmacol. 2026 Jun;511:117785. doi: 10.1016/j.taap.2026.117785. Epub 2026 Mar 7. Toxicol Appl Pharmacol. 2026. PMID: 41802575 Free PMC article.
METHODS: We made three comparisons in anesthetized and spontaneously breathing rats: (1) the cardiorespiratory responses to IVb injection of dermorphin without and with naloxonazine (a mu(1)-OR antagonist) pretreatment; (2) the reproducibility of the responses to IVb injec …
METHODS: We made three comparisons in anesthetized and spontaneously breathing rats: (1) the cardiorespiratory responses to IVb injection of …
Dermorphin analogues containing D-kyotorphin: structure-antinociceptive relationships in mice.
Kisara K, Sakurada S, Sakurada T, Sasaki Y, Sato T, Suzuki K, Watanabe H. Kisara K, et al. Br J Pharmacol. 1986 Jan;87(1):183-9. doi: 10.1111/j.1476-5381.1986.tb10170.x. Br J Pharmacol. 1986. PMID: 2869809 Free PMC article.
Intracerebroventricular (i.c.v.) administration of dermorphin and [D-Arg2] dermorphin produced potent and long-lasting antinociceptive activity as assayed by the tail-pressure test. Dermorphin and [D-Arg2] dermorphin were 210 and 52 times more potent t …
Intracerebroventricular (i.c.v.) administration of dermorphin and [D-Arg2] dermorphin produced potent and long-lasting antinoc …
Dermorphin [D-Arg2, Lys4] (1-4) amide inhibits below-level heat hypersensitivity in mice after contusive thoracic spinal cord injury.
Liu S, Huang Q, He S, Chen Z, Gao X, Ma D, Duan W, Ford N, Yang F, Chen X, Raja SN, Hao D, Guan Y. Liu S, et al. Pain. 2019 Dec;160(12):2710-2723. doi: 10.1097/j.pain.0000000000001671. Pain. 2019. PMID: 31365470
At 6 weeks, we tested the effect of subcutaneous (s.c.) injection of dermorphin [D-Arg2, Lys4] (1-4) amide (DALDA), a peripherally acting MOR-preferring agonist, on mechanical and heat hypersensitivity. ...
At 6 weeks, we tested the effect of subcutaneous (s.c.) injection of dermorphin [D-Arg2, Lys4] (1-4) amide (DALDA), a peripherally ac …
586 results