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A peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neurons.
Aldrian-Herrada G, Desarménien MG, Orcel H, Boissin-Agasse L, Méry J, Brugidou J, Rabié A. Aldrian-Herrada G, et al. Among authors: desarmenien mg. Nucleic Acids Res. 1998 Nov 1;26(21):4910-6. doi: 10.1093/nar/26.21.4910. Nucleic Acids Res. 1998. PMID: 9776752 Free PMC article.
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