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A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains.
Martens E, Leyssen A, Van Aelst I, Fiten P, Piccard H, Hu J, Descamps FJ, Van den Steen PE, Proost P, Van Damme J, Liuzzi GM, Riccio P, Polverini E, Opdenakker G. Martens E, et al. Among authors: descamps fj. Biochim Biophys Acta. 2007 Feb;1770(2):178-86. doi: 10.1016/j.bbagen.2006.10.012. Epub 2006 Oct 26. Biochim Biophys Acta. 2007. PMID: 17137715
Remnant epitopes, autoimmunity and glycosylation.
Opdenakker G, Dillen C, Fiten P, Martens E, Van Aelst I, Van den Steen PE, Nelissen I, Starckx S, Descamps FJ, Hu J, Piccard H, Van Damme J, Wormald MR, Rudd PM, Dwek RA. Opdenakker G, et al. Among authors: descamps fj. Biochim Biophys Acta. 2006 Apr;1760(4):610-5. doi: 10.1016/j.bbagen.2005.12.014. Epub 2006 Jan 6. Biochim Biophys Acta. 2006. PMID: 16439062 Review.
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