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Macrophage cytokines: involvement in immunity and infectious diseases.
Arango Duque G, Descoteaux A. Arango Duque G, et al. Front Immunol. 2014 Oct 7;5:491. doi: 10.3389/fimmu.2014.00491. eCollection 2014. Front Immunol. 2014. PMID: 25339958 Free PMC article. Review.
A portfolio of cytokines is central to the role of macrophages as sentries of the innate immune system that mediate the transition from innate to adaptive immunity. In concert with other mediators, cytokines bias the fate of macrophages into a spectrum of inflammati
A portfolio of cytokines is central to the role of macrophages as sentries of the innate immune system that mediate the transition fr
Protein kinase C-alpha modulates lipopolysaccharide-induced functions in a murine macrophage cell line.
St-Denis A, Chano F, Tremblay P, St-Pierre Y, Descoteaux A. St-Denis A, et al. J Biol Chem. 1998 Dec 4;273(49):32787-92. doi: 10.1074/jbc.273.49.32787. J Biol Chem. 1998. PMID: 9830023
To this end, we have stably overexpressed a dominant-negative (DN) version of PKC-alpha (DN PKC-alpha) in the murine macrophage cell line RAW 264. 7. ...DN-PKC-alpha overexpression did not cause a general unresponsiveness to LPS, as secretion of the matrix metallopr …
To this end, we have stably overexpressed a dominant-negative (DN) version of PKC-alpha (DN PKC-alpha) in the murine macrophage cell …
Role of protein kinase C-alpha in the control of infection by intracellular pathogens in macrophages.
St-Denis A, Caouras V, Gervais F, Descoteaux A. St-Denis A, et al. J Immunol. 1999 Nov 15;163(10):5505-11. J Immunol. 1999. PMID: 10553077
To this end, we used clones of the murine macrophage cell line RAW 264.7 overexpressing a dominant-negative (DN) mutant of PKC-alpha. ...Permissiveness to L. pneumophila was not the consequence of a general defect in the microbicidal capacities because killing of …
To this end, we used clones of the murine macrophage cell line RAW 264.7 overexpressing a dominant-negative (DN) mutant of PKC-alpha. …
Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1/2 during infection of naive macrophages.
Privé C, Descoteaux A. Privé C, et al. Eur J Immunol. 2000 Aug;30(8):2235-44. doi: 10.1002/1521-4141(2000)30:8<2235::AID-IMMU2235>3.0.CO;2-9. Eur J Immunol. 2000. PMID: 10940915
Cyclooxygenase-2 expression in macrophages: modulation by protein kinase C-alpha.
Giroux M, Descoteaux A. Giroux M, et al. J Immunol. 2000 Oct 1;165(7):3985-91. doi: 10.4049/jimmunol.165.7.3985. J Immunol. 2000. PMID: 11034408
Previous studies with pharmacological inhibitors suggested a role for protein kinase C (PKC) in PG production possibly by regulating COX-2 expression. ...Measurements of PGE2 levels revealed a strong correlation between PGE2 secretion and IFN-gamma-induced COX-2 mRN …
Previous studies with pharmacological inhibitors suggested a role for protein kinase C (PKC) in PG production possibly by regulating …
Modulation of lipopolysaccharide-induced NF-IL6 activation by protein kinase C-alpha in a mouse macrophage cell line.
Chano F, Descoteaux A. Chano F, et al. Eur J Immunol. 2002 Oct;32(10):2897-904. doi: 10.1002/1521-4141(2002010)32:10<2897::AID-IMMU2897>3.0.CO;2-J. Eur J Immunol. 2002. PMID: 12355443
We have previously shown that overexpression of a dominant-negative (DN) mutant of protein kinase C-alpha (PKC-alpha) in RAW 264.7 macrophages inhibited lipopolysaccharide (LPS)-induced IL-1alpha, inducible nitric oxide synthase and cyclooxygenase-2 expression. ...Converse …
We have previously shown that overexpression of a dominant-negative (DN) mutant of protein kinase C-alpha (PKC-alpha) in RAW 264.7 ma …
IFN-gamma-induced MHC class II expression: transactivation of class II transactivator promoter IV by IFN regulatory factor-1 is regulated by protein kinase C-alpha.
Giroux M, Schmidt M, Descoteaux A. Giroux M, et al. J Immunol. 2003 Oct 15;171(8):4187-94. doi: 10.4049/jimmunol.171.8.4187. J Immunol. 2003. PMID: 14530341
Previous studies based on pharmacological evidence suggested a requirement for protein kinase C (PKC) activity in the regulation of IFN-gamma-induced MHC class II (MHC-II) expression. ...Collectively, our data suggest a novel regulatory mechanism for IFN-gamma-induc …
Previous studies based on pharmacological evidence suggested a requirement for protein kinase C (PKC) activity in the regulation of I …
Modulation of phagolysosome biogenesis by the lipophosphoglycan of Leishmania.
Lodge R, Descoteaux A. Lodge R, et al. Clin Immunol. 2005 Mar;114(3):256-65. doi: 10.1016/j.clim.2004.07.018. Clin Immunol. 2005. PMID: 15721836 Review.
A family of glycoconjugates, the phosphoglycans (PGs), plays an important role in the ability of promastigotes to survive the potentially microbicidal consequences of phagocytosis. ...This inhibition correlates with an accumulation of periphagosomal F-actin, which may pote
A family of glycoconjugates, the phosphoglycans (PGs), plays an important role in the ability of promastigotes to survive the potenti
RNA interference reveals a role for TLR2 and TLR3 in the recognition of Leishmania donovani promastigotes by interferon-gamma-primed macrophages.
Flandin JF, Chano F, Descoteaux A. Flandin JF, et al. Eur J Immunol. 2006 Feb;36(2):411-20. doi: 10.1002/eji.200535079. Eur J Immunol. 2006. PMID: 16369915
Leishmania donovani promastigotes evade the induction of a proinflammatory response during their invasion of naive macrophages. ...Furthermore, our data indicate a participation of TLR2 and TLR3 in the phagocytosis of L. donovani promastigotes and a role for …
Leishmania donovani promastigotes evade the induction of a proinflammatory response during their invasion of naive macrophages. ...Fu …
Phagocytosis of Leishmania donovani amastigotes is Rac1 dependent and occurs in the absence of NADPH oxidase activation.
Lodge R, Descoteaux A. Lodge R, et al. Eur J Immunol. 2006 Oct;36(10):2735-44. doi: 10.1002/eji.200636089. Eur J Immunol. 2006. PMID: 16955522
Consistently, we observed that amastigotes induced barely detectable phosphorylation of the NADPH oxidase component p47phox, leading to a defective phagosomal recruitment of p67phox and p47phox. ...Collectively, our results indicate that internalization of L. donovani amas …
Consistently, we observed that amastigotes induced barely detectable phosphorylation of the NADPH oxidase component p47phox, leading to a
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