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Immune control of HIV-1 reservoirs.
Autran B, Descours B, Bacchus C. Autran B, et al. Among authors: descours b. Curr Opin HIV AIDS. 2013 May;8(3):204-10. doi: 10.1097/COH.0b013e32835fe6d2. Curr Opin HIV AIDS. 2013. PMID: 23493099 Review.
Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells.
Bermejo M, López-Huertas MR, García-Pérez J, Climent N, Descours B, Ambrosioni J, Mateos E, Rodríguez-Mora S, Rus-Bercial L, Benkirane M, Miró JM, Plana M, Alcamí J, Coiras M. Bermejo M, et al. Among authors: descours b. Biochem Pharmacol. 2016 Apr 15;106:30-45. doi: 10.1016/j.bcp.2016.02.002. Epub 2016 Feb 4. Biochem Pharmacol. 2016. PMID: 26851491
Immune responses driven by protective human leukocyte antigen alleles from long-term nonprogressors are associated with low HIV reservoir in central memory CD4 T cells.
Descours B, Avettand-Fenoel V, Blanc C, Samri A, Mélard A, Supervie V, Theodorou I, Carcelain G, Rouzioux C, Autran B; ALT ANRS CO15 Study Group. Descours B, et al. Clin Infect Dis. 2012 May;54(10):1495-503. doi: 10.1093/cid/cis188. Epub 2012 Mar 22. Clin Infect Dis. 2012. PMID: 22441653
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study.
Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C; ANRS VISCONTI Study Group. Sáez-Cirión A, et al. Among authors: descours b. PLoS Pathog. 2013 Mar;9(3):e1003211. doi: 10.1371/journal.ppat.1003211. Epub 2013 Mar 14. PLoS Pathog. 2013. PMID: 23516360 Free PMC article.
Elite controllers as a model of functional cure.
Autran B, Descours B, Avettand-Fenoel V, Rouzioux C. Autran B, et al. Among authors: descours b. Curr Opin HIV AIDS. 2011 May;6(3):181-7. doi: 10.1097/COH.0b013e328345a328. Curr Opin HIV AIDS. 2011. PMID: 21460722 Review.
HIV-1 genome is often defective in PBMCs and rectal tissues after long-term HAART as a result of APOBEC3 editing and correlates with the size of reservoirs.
Fourati S, Lambert-Niclot S, Soulie C, Malet I, Valantin MA, Descours B, Ait-Arkoub Z, Mory B, Carcelain G, Katlama C, Calvez V, Marcelin AG. Fourati S, et al. Among authors: descours b. J Antimicrob Chemother. 2012 Oct;67(10):2323-6. doi: 10.1093/jac/dks219. Epub 2012 Jun 11. J Antimicrob Chemother. 2012. PMID: 22687892
Direct quantification of cell-associated HIV DNA in isolated rectal and blood memory CD4 T cells revealed their similar and low infection levels in long-term treated HIV-infected patients.
Descours B, Lambert-Niclot S, Mory B, Samri A, Charlotte F, Peytavin G, Tubiana R, Papagno L, Bacchus C, Lecardonnel F, Katlama C, Autran B, Marcelin AG, Valantin MA, Carcelain G; DECAMUNE and ORVACS Study Groups. Descours B, et al. J Acquir Immune Defic Syndr. 2013 Mar 1;62(3):255-9. doi: 10.1097/QAI.0b013e318282537f. J Acquir Immune Defic Syndr. 2013. PMID: 23274932
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